Image analysis – Applications – Biomedical applications
Reexamination Certificate
2008-01-08
2008-01-08
Ahmed, Samir (Department: 2624)
Image analysis
Applications
Biomedical applications
C435S006120, C702S019000, C702S020000
Reexamination Certificate
active
07317820
ABSTRACT:
A digital image processing-based system and method for quantitatively processing a plurality of nucleic acid species expressed in a microarray are disclosed. The microarray is a grid of a plurality of sub-grids of the nucleic acid species. The system includes a scanner that has a digital scanning sensor that scans the microarray and transmits from an output a digital image of the microarray, and a computer that receives the digital image of the microarray from the scanner and then processes the digital image, identifying each of the microarray's sub-grids. The computer identifies the position of each of the sub-grids by (a) identifying regions in the digital image that each contains one of the sub-grids, (b) identifying rows and columns in each region where nucleic acid species are expressed to form a set of candidate sub-grids in each region, (c) selecting for each region a probable sub-grid from the set of candidate sub-grids in each region, and (d) comparing the positions of the probable sub-grids from each region to finalize the sub-grid positions.
REFERENCES:
patent: 5970164 (1999-10-01), Bamberger et al.
patent: 6054270 (2000-04-01), Southern
patent: 6127129 (2000-10-01), Corn et al.
patent: 6226542 (2001-05-01), Reisfeld
patent: 6251601 (2001-06-01), Bao et al.
patent: 6263092 (2001-07-01), Roehrig et al.
patent: 6301378 (2001-10-01), Karssemeijer et al.
patent: 6345115 (2002-02-01), Ramm et al.
patent: 6537749 (2003-03-01), Kuimelis et al.
Chen, Dougherty, Bittner, Biomedical Optics, “Ratio-Based Decisions and the Quantitative Analysis of cDNA Microarray Images” (Oct. 1997), pp. 364-374.
Schena, Shalon, Davis, Brown, Science, “Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray” (Oct. 20, 1995), vol. 270, pp. 467-470.
Schena, BioEssays, “Genome analysis with gene expression microarrays,” (Jan. 3, 1996), vol. 18 No. 5, pp. 427-431.
Lemieux, Aharoni, and Schena, Molecular Breeding, “Overview of DNA chip technology,” (1998), pp. 277-289.
Schena, Heller, Theriault, Konrad, Lachenmeier, Davis, Tibtech, “Microarrays: biotechnology's discovery platform for functional genomics,” (Jul. 1998), vol. 16, pp. 301-306.
Schena, Shalon, Heller, Chai, Brown, Davis, Biochemistry, “Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes,” (Oct. 1996), vol. 93, pp. 10614-10619.
Heller, Schena, Chai, Shalon, Bedilion, Gilmore, Woolley, Davis, Biochemistry, “Discovery and analysis of inflammatory disease-related genes using cDNA microarrays,” (Mar. 1997), vol. 94, pp. 2150-2155.
Schena, Davis, PCR Methods Manual, “Parallel Analysis with Biological Chips,” pp. 445-455.
Schena, Davis, DNA Microarray Protocols.
Arraylt, Chip Maker 2 Handbook, “Micro-Spotting Device For a Broad Range of Microarray Manufacturing Applications,” (Jun. 1, 1998).
Arraylt, Chip Maker 3 Handbook, “Micro-Spotting Device For a Broad Range of Microarray Manufacturing Applications,” (Dec. 8, 1998).
Arraylt, 96 & 384 Well PCR Purification Kits, “High through put purification of PCR products for DNA microarrays, sequencing and other applications in genomics”.
Arraylt, Hybridization Cassette Handbook, “Designed for hybridization reactions involving nucleic acid microarray biochips,” (1998).
Arraylt, Micro-Spotting Solution (2X) Handbook, “Advanced polymeric mixture designed to increase the quality of microarray biochip fabrication by improving the surface properties of the DNA micro-spotting technologies,” (1998).
Arraylt, UniHyb Hybridization Solution Handbook, “An advanced mixture of salts, detergents and buffering components . . . ,” (1998).
Arraylt, Dye Terminator Clean-Up Kits Handbook, (1998).
Ahmed Samir
BioDiscovery, Inc
Tabatabai Abolfazl
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