System and method for automatically detecting malignant cells an

Image analysis – Applications – Biomedical applications

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

382128, G06K 900

Patent

active

060261749

ABSTRACT:
A system and method for detecting diagnostic cells and cells having malignancy-associated changes are disclosed. The system includes an automated classifier having a microscope, camera, image digitizer, a computer system for controlling and interfacing these components, a primary classifier for initial cell classification, and a secondary classifier for subsequent cell classification. The method utilizes the automated classifier to automatically detect diagnostic cells and cells having malignancy-associated changes. The system and method are particularly useful for detecting these cells in cell samples obtained from bronchial specimens such as lung sputum.

REFERENCES:
patent: 3857033 (1974-12-01), Cobb
patent: 4362386 (1982-12-01), Matsushita et al.
patent: 4453266 (1984-06-01), Bacus
patent: 4513438 (1985-04-01), Graham et al.
patent: 4562593 (1985-12-01), Ooe et al.
patent: 4700298 (1987-10-01), Palcic et al.
patent: 4702595 (1987-10-01), Mutschler et al.
patent: 4741043 (1988-04-01), Bacus
patent: 4907158 (1990-03-01), Kettler et al.
patent: 4965725 (1990-10-01), Rutenberg
patent: 4998284 (1991-03-01), Bacus et al.
patent: 5016283 (1991-05-01), Bacus et al.
patent: 5031099 (1991-07-01), Kettler
patent: 5072382 (1991-12-01), Kamentsky
patent: 5073857 (1991-12-01), Peters et al.
patent: 5099521 (1992-03-01), Kosaka
patent: 5109429 (1992-04-01), Bacus et al.
patent: 5281517 (1994-01-01), Bacus et al.
patent: 5287272 (1994-02-01), Rutenberg et al.
patent: 5317644 (1994-05-01), Kenyon et al.
patent: 5485527 (1996-01-01), Bacus et al.
patent: 5544650 (1996-08-01), Boon et al.
patent: 5627908 (1997-05-01), Lee et al.
Bertrand, Dominique, et al., "Basic of Video Image Analysis," Trends in Analytical Chemistry, vol. 10, No. 8, Sep. 1991, pp. 237-243.
Bibbo, Marluce et al., "Chromatin Appearance in Intermediate Cells from Patients with Uterine Cancer," Acta Cytologica, vol. 25, No. 1, Jan.-Feb. 1981, pp. 23-28.
BMDP Statistical Software Manual, vol. 2, extract, University of California Press, 1988.
Bulstra, S.K., et al., "Thionin Staining of Paraffin and Plastic Embedded Sections of Cartilage," Biotechnic & Histochemistry, vol. 68, No. 1, 1993, pp. 20-28.
Burger, G. et al., "Changes in benign cell population in cases of cervical cancer and its precursors," Analytical and Quantitative Cytology, vol. 3, 1981, pp. 261-271.
Cooper, J.D., et al., "Accurate Counting of Neurons in Frozen Sections: Some Necessary Precautions," J. Anatomy, vol. 157, 1988, pp. 13-21.
Danielsson, Per-Erik, "A New Shape Factor," Computer Graphics and Image Processing, vol. 7, 1978, pp. 292-299.
Doudkine, A., et al., "Nuclear Texture Measurements in Image Cytometry," Pathologica, vol. 87, 1995, pp. 286-299.
Eddy, D.M., "Screening for Lung Cancer," Annals of Internal Medicine, vol. 111, No. 3, Aug. 1, 1989, pp. 232-237.
Feulgen, R., et al., Z. Physiol. Chem. vol. 136, 1924, pp. 57-61.
Galloway, Mary M., "Texture Analysis Using Gray Level Run Lengths," Computer Graphics and Image Processing, vol. 4, 1975, pp. 172-179.
Garner, D.M., "The Cyto-Savant.TM. System," The Automation of Cervical Cancer Screening, H.K. Grohs et al., eds., Igakuk-Shoin Medical Publishers, Inc., New York, New York, 1994.
Garner, D.M., et al., "CytoSavant and Its Use in Automated Screening of Cervical Smears," in Compendium on the Computerized Cytology and Histology Laboratory, Wied, G.L., et al., eds., Tutorials of Cytology, Chicago, IL, 1994, pp. 346-352.
Holmquist, J. et al., "Computer Analysis of Cervical Cells Automatic Feature Extraction and Classification," The Journal of Histochemistry and Cytochemistry, vol. 26, No. 11, 1978, pp. 100-1017.
Humason, Gretchen L., Animal Tissue Techniques, 4th Ed., W.H. Freeman & Company, San Francisco, 1979, pp. 154-155, 181-183, 208, 316-319, 432-433, 471-473.
Insausti, R., et al., "The Human Entorhinal Cortex: A Cytoarchitectonic Analysis," The Journal of Comparative Neurology, vol. 355, 1995, pp. 171-198.
Jaggi, B., et al., "Design of a Solid-State Microscope," Optical Engineering, Jun. 1989, vol. 28 No. 6, pp. 675-682.
Jaggi, B., et al., "The Design and Development of an Optical Scanner for Cell Biology," IEEE Proceedings Engineering in Medicine and Biology Society, vol. 2, Sep. 1985; pp. 980-985.
Katzko, Michael W. et al., "Carcinoma In Situ Specimen Classification Based on Intermediate Cell Measurements," Cytometry, vol. 8, 1987, pp. 9-13.
Klawe, H. et al., "Malignancy associated changes (MAC) in cells of buccal smears detected by means of objective image analysis," Acta Cytologica, vol. 18, 1974, pp. 30-33.
Komitowski, D. et al., "Quantitative Description of Chromatin Structure During Neoplasia by the Method of Image Processing," Analytical and Quantitative Cytology and Histology, vol. 7, No. 3, Sep. 1985, pp. 178-182.
Kutscher, Charles L., et al., "Hematoxylin and Thionin Techniques for Staining Myelin and Cells: Variations and Critical Steps," Brain Research Bulletin, vol. 19, 1987, pp. 161-163.
Lockart, Royce Z., "Features Independent of Stain Intensity for Evaluating Feulgen-Stained Cells," Analytical and Quantitative Cytology, vol. 6, No. 2, Jun. 1984, pp. 105-111.
MacAulay, C. et al., "Fractal Texture Features Based on Optical Density Surface Area: Use in Image Analysis of Cervical Cells," Analytical and Quantitative Cytology and Histology, vol. 12, No. 6, Dec. 1990, pp. 394-398.
MacAulay, C. et al., "Malignancy-Associated Changes in Bronchial Epithelial Cells in Biopsy Specimens," Analytical and Quantitative Cytology and Histology, vol. 17, No. 1, Feb. 1995, pp. 55-61.
MacAulay, Calum and Branko Palcic, "An Edge Relocation Segmentation Algorithm," Analytical and Quantitative Cytology and Histology, vol. 12, No. 3, Jun. 1990, pp. 165-171.
Mickel, Ulrika V., et al., "A Comparative Study of Quantitative Stains for DNA in Image Cytometry," Analytical and Quantitative Cytology and Histology, vol. 13, No. 4, Aug. 1991, pp. 253-260.
Muto, Tetsuichiro, et al., "Mucin Abnormality in Colonic Mucosa in Patients with Familial Polyposis Coli," Seminars in Surgical Oncology, vol. 3, 1987, pp. 179-182.
Nieburgs, H.E. et al., "Systemic Cellular Changes in Material from Human and Animal Tissues," Transactions, 7th Annual Meeting Inter. Soc. Cytol. Council, 1959, pp. 137-144.
Ota, H., et al., "A Dual Staining Method for Identifying Mucins of Different Gastric Epithelial Mucous Cells," Histochemical Journal, vol. 23, 1991, pp. 22-28.
Palcic, B. et al., "Algorithms in Preparation for Decision-Making," The Automation of Cervical Cancer Screening, H.K. Grohs et al., eds., Igaku-Shoin Medical Publishers, Inc., N.Y., N.Y., 1994.
Palcic, B. et al., "Malignancy Associated Changes (MACs) and their Use in the Diagnosis and Prognosis of Early Cancer," presented at the Eighth International Meeting of the Adriatic Society of Pathology, Italy, Jun. 26-27, 1993.
Palcic, B. et al., "Malignancy Associated Changes: Can They be Employed Clinically?" Compendium on the Computerized Cytology and Histology Laboratory, George L. Wied et al., eds., Tutorials of Cytology, Chicago, Illinois, 1994, pp. 157-165.
Palcic, B. et al., "Quantitative Evaluation of Malignant Potential of Early Breast Cancer Using High Resolution Image Cytometry," presented at Chemoprevention of Breast Cancer: Surrogate Endpoints and Chemopreventive Agents in Short-term Clinical Trials, sponsored by the National Cancer Institute, Lake Tahoe, California, Oct. 5-10, 1993.
Payne, P.W. et al., "Diagnostic Variation on Bronchial Biopsy Specimens: Differential Diagnosis by Quantitative Features," presented at the XVI Congress of the International Society for Analytic Cytology, Colorado Springs, Colorado, Mar. 21-26, 1993; Cytometry Supplement, vol. 6, No. 84, Abstract #442, 1993.
Peet, F.G. et al., "A Computer-Assisted Cell Identification System," Analytical and Quantitative Cytology, vol. 6, No. 1, Mar. 1984, pp. 59-70.
Poon, S.S.S., et al., "Cell Recognition Algorithms for the Cell Analyzer," IEEE Proceedings Engineering in Medicine and Biology Society, vol. 4, Nov. 1987; pp. 1454-1456.
Pressman, Norman J., "Markovian Analysis of Cervical Cell Images," The Journa

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

System and method for automatically detecting malignant cells an does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with System and method for automatically detecting malignant cells an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System and method for automatically detecting malignant cells an will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1912186

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.