Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Reexamination Certificate
2005-08-09
2005-08-09
Mendez, Manuel (Department: 3763)
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
Reexamination Certificate
active
06928318
ABSTRACT:
A system and method for assessing the performance of a system for delivering a pharmaceutical agent to a portion of a body. A pair of electrodes are applied to the portion of the body. A pharmaceutical agent is infused into the portion of the body and the electrodes are energized by a signal generator, electrically stimulating the portion of the body. The voltage and current delivered to the portion of the body are measured using a data acquisition system thereby generating electrical parameter data. An immune response, gene expression level or other biological response to the pharmaceutical agent is measured and the electrical test data is correlated with the biological response to assess the performance of the system.
REFERENCES:
patent: 4383529 (1983-05-01), Webster
patent: 4406658 (1983-09-01), Lattin et al.
patent: 4702732 (1987-10-01), Powers et al.
patent: 5273525 (1993-12-01), Hofmann
patent: 5439440 (1995-08-01), Hofmann
patent: 5501662 (1996-03-01), Hofmann
patent: 5507724 (1996-04-01), Hofmann et al.
patent: 5515848 (1996-05-01), Corbett, III et al.
patent: 5545130 (1996-08-01), Hofmann et al.
patent: 5676646 (1997-10-01), Hofmann et al.
patent: 5702359 (1997-12-01), Hofmann et al.
patent: 5704908 (1998-01-01), Hofmann et al.
patent: 5810762 (1998-09-01), Hofmann
patent: 5869326 (1999-02-01), Hofmann
patent: 5968006 (1999-10-01), Hofmann
patent: 5983131 (1999-11-01), Weaver et al.
patent: 6047208 (2000-04-01), Flower
patent: 6654636 (2003-11-01), Dev et al.
patent: WO98/43702 (1998-10-01), None
patent: WO99/01157 (1999-01-01), None
patent: WO99/01158 (1999-01-01), None
patent: WO99/01175 (1999-01-01), None
Jaroszeski et al.,Advanced Drug Delivery Reviews, 35, 1999, pp. 131-137.
Widera et al.,J. Immunology, 2000, pp. 4635-4640.
Vicat et al.,Human Gene Therapy, 2000, pp. 909-916.
Aihara and Miyazaki,Nature Biotechnology, 1998, pp. 867-870.
Ros, et al.,Nature Biotechnology, 1998, pp. 168-171.
Muramatsu, et al.,Biochem. Biophys. Res. Comm., 1997, pp. 45-59.
Zhang, et al.,Biochem. Biophys. Res. Comm., 1996, pp. 633-636.
Nishi, et al.,Cancer Res., 1996, pp. 1050-1055.
Heller, et al.,FEBS Letters, 1996, pp. 225,228.
Titomirov, et al.,Biochem. Biophys. Acta, 1991, pp. 131-134.
Mathiesen,Gene Therapy, 1999, pp. 508-514.
Bureau, et al.,Importance of Association Between Permeablization and Electrophoretic Force: for Intramuscular DNA Electrotransfer, Biochimica et Biophysica Acta, vol. 1474, No. 3, pp 353-359 (May 1, 2000).
Oshima, et al.,Targeted Gene Transfer to Corneal Endothelium in vivo by Electric Pulse, Gene Therapy, vol. 5, No. 10, pp 1347-1354 (Oct., 1998).
Zhang, et al.,In Vivo Transdermal Delivery of Large Molecules by Pressure-Mediated Electroincorporation and Electroporation: A Novel Method for Drug and Gene Delivery, Bioelectrochemistry and Bioenergetics, vol. 42, pp 283-292 (1997).
Duane Morris LLP
Mendez Manuel
Merck & Co. , Inc.
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