Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1984-06-13
1987-06-16
Pellegrino, Stephen C.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604224, 604187, 604244, A61M 500
Patent
active
046733965
DESCRIPTION:
BRIEF SUMMARY
FIELD OF INVENTION
The present invention is directed to a syringe cartridge, which provides for controlled or zero head clearance with the contents, thereby isolating the contents from ambient air.
SUMMARY OF THE PRIOR ART
Measurement of human blood gases is a well known medical test and is routinely performed with specialized blood gas instruments. These instruments must be frequently tested for accuracy and calibration to insure that reliable measurements are being made. Recently the advantages of using gas equilibrated, buffered, stabilized human blood cell suspensions as quality control specimens to be run in conjunction with patient specimens have been described. See for example U.S. Pat. No. 4,126,575 to Louderback. However, such blood gas control material requires special handling, including incubation and agitation prior to use, and avoidance of contact with air.
An attempt was made by Intensive Technology, Inc. of 25 Bay State Road, Boston, Mass., in a product called "Respatrol" to minimize the above problems by sealing the blood gas control with a gel. However, the integrity of the seals as well as opening and resealing of the ampules was less than satisfactory.
It thus becomes highly desirable, in view of the prior art and the problems, to provide for zero head space in a cartridge, and continuing zero head space during the dispensing of the contents of the cartridge, particularly where whole blood or other ingredients are involved that must be sealed from ambient air. It is further desirable to accomplish such a packaging with resealable and reclosure features which constantly inhibit the ingress of air into the container. In addition, it is desirable to be able to dispense the entire contents accurately and without contamination by air after repeated usage and resealing. Where the cartridge will be used numerous times for very small microsamples, there is a possibility of drawback of ambient air, and the formation of bubbles. By micrometering with a high degree of precision, this problem can be minimized.
SUMMARY OF THE INVENTION
The present invention is directed to a cartridge which is filled and can be subsequently capped and closed. This is done by filling to a discrete level and then applying a closure. The closure bottom displaces a predetermined amount of air or gas and a small amount of product from the interior of the cartridge. The entirety of the process of filling is done in a vented environment, and the closure applied at ambient. The invention also provides a syringe cartridge having its open lower portion closed by a plunger piston. The upper portion is closed by a syringe cartridge closure having a leur tip cap. Means are optionally provided interiorly of the tip cap to retain a hollow needle, which is held in position by a leur tip, the latter being vented and provided with a seal for the needle. A displacement dome is provided at the lower portion of the syringe cartridge closure to displace a minor amount of fluid upon closure to seal the cartridge, and insure zero head space. The piston plunger at the lower portion of the cartridge can be advanced, desirably by a second plunger, to empty the contents. Upon resealing, the leur tip cap is applied over the leur tip after a bead is formed on the tip. The tip cap then penetrates the leur tip, or optionally the interior of the hollow needle thus completely reclosing the cartridge and sealing the same for storage until intended for further use. Optionally, a metered screw plunger system is employed. In this alternative embodiment where micrometering is desired, a metered screw plunger system is utilized. This permits precise samples to be withdrawn and inhibits drawback or retraction of the system which inherently is vulnerable to bubble entrapment in the solution.
In view of the foregoing it is a principal object of the present invention to provide a syringe cartridge with zero head space in the interior to eliminate ambient air. A related advantage stems from the use of the subject product with a whole blood control so tha
REFERENCES:
patent: 1707880 (1929-04-01), Sheets
patent: 2431985 (1947-12-01), Bowman et al.
patent: 2736315 (1956-02-01), Feeney
patent: 4044758 (1977-08-01), Patel
patent: 4057050 (1977-11-01), Sarstedt
patent: 4289648 (1981-09-01), Hoskins et al.
patent: 4291701 (1981-09-01), Bowman
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