Syringe and method for lyophilizing and reconstituting injectabl

Details Syringe and method for lyophilizing and reconstituting injectabl Syringe and method for lyophilizing and reconstituting injectabl

1996-04-08

1998-05-19

Buiz, Michael Powell

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

604 56, 604 82, 604416, 206219, A61M 500, A61B 1900

Patent

active

057529400

ABSTRACT:
A syringe assembly includes a substantially cylindrical syringe barrel and a plunger stopper. Distal portions on the plunger stopper are configured to permit outflow of vapor from the syringe barrel during a lyophilization process. Proximal portions of the plunger stopper are dimensioned to engage the syringe barrel in sliding fluid-tight engagement. Liquid medication in the chamber is lyophilized and a vacuum is applied to the syringe barrel after lyophilization. The plunger stopper then is urged distally into sealing engagement with the syringe barrel. A plunger rod can be engaged with the plunger stopper. The tip cap is then removed and a diluent is drawn into the chamber by moving the plunger rod and the plunger stopper in a proximal direction. The syringe assembly then can be used in the standard manner.

REFERENCES:
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patent: 3052240 (1962-09-01), Silver et al.
patent: 3164303 (1965-01-01), Trautmann
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patent: 3330282 (1967-07-01), Visser et al.
patent: 3901402 (1975-08-01), Ayres
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patent: 4599082 (1986-07-01), Grimard
patent: 4613326 (1986-09-01), Szwarc
patent: 4952208 (1990-08-01), Lix
patent: 5236420 (1993-08-01), Pfleger

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