Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Carbohydrate or lignin – or derivative
Reissue Patent
2011-03-22
2011-03-22
Krass, Frederick (Department: 1612)
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Carbohydrate or lignin, or derivative
C514S912000
Reissue Patent
active
RE042243
ABSTRACT:
A viscoelastic composition for injection into a human eye comprised of about 2.0 to 2.5 percent of hydroxypropyl methylcellulose dissolved in a physiological salt solution, the composition, the composition having a viscosity from about 15,000 to about 40,000 centipoise and the hydroxypropyl methylcellulose having a molecular weight from about 220,000 to less than about 420,000 Daltons, the composition being free of debris or gels greater than 0.5 μm. Also described is a process for preparing the clean, high molecular weight hydroxy propylmethyl cellulose composition.
REFERENCES:
patent: 4343787 (1982-08-01), Katz
patent: 4819617 (1989-04-01), Goldberg et al.
patent: 4853374 (1989-08-01), Allen
patent: 5013714 (1991-05-01), Lindstrom et al.
patent: 5218107 (1993-06-01), Schulz
patent: 2204238 (1988-11-01), None
patent: 62-122671 (1987-06-01), None
patent: 62-266056 (1987-11-01), None
Kasahara, A., “2% Methylcellulose. Preparation of 2% Methylcellulose” (instruction brochure), Institute of Clinical Ophthalmology, 1-100 Umeda Kiryu Gunma, Japan [undated].
Arshinoff, S. “Comparative Physical Properties of Ophthalmic Viscoelastic Materials”Ophthalmic Practice7(1):16-18, 36-37 (1989).
Arshinoff, S. “The Physical Properties of Ophthalmic Viscoelastics in Cataract Surgery”National Ophthalmic Speakers Programpp. 7-12 (1992).
Arshinoff, S. “The Safety and Perfomance of Ophthalmic Viscoelastics in Cataract Surgery and Its Complications”Proceedings of the 6th Annual National Ophthalmic Speakers Programpp. 21-28 (1994).
Bigar, F. et al. “The Tolerance of Hydroxypropylmethylcellulose in Implantation of Posterior Chamber Lenses”Klin Monatsbi Augenheilkd193(1):21-24 (Jul. 1988).
Bothner, H., et al. “Rheology of Intraocular Solutions”Viscoelastic Materials Vision and Visual Health Care2:53-70 (1986).
Dow Chemical “How to Improve Pharmaceutical Formulations with Methocel and Ethocel Cellulose Ethers” (Oct. 1995).
Dow Chemical “Methocel Cellulose Ethers Technical Handbook” pp. 1-24 (Apr. 1988).
Dow Chemical “Formulating for Controlled Release with Methocel Cellulose Ethers” pp. 1-9 (Mar. 1987).
Dow Chemical Sales Specification—Methocel K100M, Sep. 4, 1991 (three pages).
Dow Chemical Sales Specification—Methocel E10M, Jun. 9, 1992 (three pages).
Fechner, P.U. “Preparation of 2% Hydroxypropyl Methylcellulose for Viscous Surgery”Am. Intraocular Implant Soc. J.vol. 11:606-607 (Nov. 1985).
Fechner, P.U. et al. “Comparison of Hydroxypropyl Methylcellulose 2% (Adatocel®)”J Cataract Refract Surgvol. 15:685-688 (Nov. 1989).
Fernandez-Vigo, et al. “Elimination of Hydroxypropylmethylcellulose from the Anterior Chamber of the Rabbit”J Cataract Refract Surg15:191 (Mar. 1989).
Hazariwala, K., et al. “Comparison of 2% Hydroxypropyl Methylcellulose and 1% Sodium Hyaluronate in Implant Surgery”Can J Opthalmol23(6):259-61 (1988).
Jacobi, K.W., et al. “Kongress der Deutschem Gesellschaft fur Intraokularlinsen Implantation,”Berlin, Springer-Verlagpp. 86-89 (1987).
McG Steele, A.D. “Hydroxpropylmethylcellulose Used as a Viscoelastic Fluid in Ocular Surgery”Visco-Elastic Materials Vision and Visual Health Care2:27-29 (1986).
“Methylcellulose,”IOL1(3):147-151 (Sep. 1987).
Momose, A. et al. “Particles in Viscosurgical Materials,”Journal of the Eye5:314-315 (1988).
Robert, Y. “Die Uberprufung der Vertraglichkeit von Intraokular Injizierter Hydroxy-propyl-methyl-cellulose (HPMC) im Tierversuch,”Klin. Mbl. Augenheilk,192:337-339, (1988).
Rosen, E.S. “The use of Hydroxypropyl Methylcellulose in Extracapsular Cataract Extraction with Intraocular Lens Implantation,”Am J. Ophthalmology,103(5):727-8 (1987).
Rosen, E.S., et al “Is 2% Hydroxypropylmethylcellulose a Safe Solution for Intraoperative Clinical Applications?”J Cataract Refract Surg,12:679-684 (Nov. 1986).
Rosen, E., et al “Some Observations on Hydroxypropylmethylcellulose”Viscoelastic Materials Vision and Visual HealthCare 2:1-7 (1986).
Vision Biology, Inc. Cellugel™ VSF (Viscoelastic Surgical Fluid) brochure (undated).
Alcon Inc.
Flanigan Mark E.
Krass Frederick
Packard Benjamin
LandOfFree
Synthetic viscoelastic material for ophthalmic applications does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthetic viscoelastic material for ophthalmic applications, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic viscoelastic material for ophthalmic applications will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2694595