Synthetic vinblastine and vincristine derivatives

Details Synthetic vinblastine and vincristine derivatives Synthetic vinblastine and vincristine derivatives

1977-06-13

1979-03-13

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424258, 465 51, 546 53, 546 50, 542430, C07D51904

Patent

active

041442377

ABSTRACT:
Novel 3',4'-dehydro- and 4'-deoxo-vincristine and vinblastine compounds are obtained by coupling an indole unit of the catharanthine series and a dihydroindole unit of the vindoline series. Representative compounds of this series showed superior results when tested for activity against L1210 and P388 mouse leukemia.

REFERENCES:
patent: 4029663 (1977-06-01), Gutowski et al.
Rahman, Pakistan J. Sci. Ind. Res., vol. 14, No. 6 (1971), pp. 487-488.
Potier et al., J. Chem. Soc., Chem. Commun. 1975 (16), 670-671, (abstract provided 83:179350c).
Kutney et al., Chem. Abst., vol. 83, abst. 28420z (1975).
Ibid, vol. 84:59,829q (1975).
Ibid, vol. 85:160,409y, Dec. 1, 1976.

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