Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1983-09-13
1991-05-21
Teskin, Robin L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 12, 514 2, 424 88, 424 89, 530324, 530325, 530326, 530327, 530826, 530806, 530807, A61K 3700, A61K 3702
Patent
active
050175580
ABSTRACT:
Novel oligopeptides are provided having serologic activity for the a determinant of hepatitis B virus surface antigen. Included in the oligopeptide chain are a sequence of at least two cysteines and a lysine in proximity to the cysteines. The oligopeptides can find use in immunoassays, the formulation of vaccines, and the production of antisera.
REFERENCES:
Arnon, Pharmac. Ther.; vol. 6, 1979, pp. 275-289, "Anti-viral activity induced by synthetic peptides corresponding to regions involved in viral neutralization".
Rao et al., Microbios, vol. 10, 1974, "Structure and activity of hepatitis B antigen (HBAg) 2 Amino acid composition . . . ".
Bancroft et al., J. Immo., vol. 109:842, 1972, "Detection of additional antigenic determinants of hepatitis B antigen".
Charnay et al., Nuc. Acid Res., vol. 7, p. 335, 1979, "Localization on the viral genane and nucleotide sequence of the gene coding for the two major polypeptides of the hepatitis B surface antigen".
Rae-Venter Barbara
Rowland Bertram I.
Teskin Robin L.
The Regents of the University of California
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