Synthetic vaccine for protection against human immunodeficiency

Details Synthetic vaccine for protection against human immunodeficiency Synthetic vaccine for protection against human immunodeficiency

1995-10-20

1999-11-30

Smith, Lynette R. F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241841, 4242081, 4242041, 530350, 530325, 530326, 530324, A61K 3921, A61K 3938, A61K 3912, C07K 100

Patent

active

059938196

ABSTRACT:
The present invention relates to immunogenic preparations of peptides comprising amino acid sequences corresponding to antigenic determinants of the envelope glycoprotein of HIV, covalently coupled, directly or through a spacer molecule, to carrier molecules suitable for vaccination of mammals.

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Palker, et al, 1988, "Type specific neutral . . . " PNAS 85: 1932-1936.
Hart, et al, "Synthetic Peptides . . . ", J. Immunol. 145(8): 2677-2685, 1990.
Javaherian, et al, 1989, "Principal Neutralizing Determinant . . . " PNAS 86: 6768-6772.
Palker, et al, "Polyvalent Human Immuno. . . " J. Immunol. 142(10): 3612-3619, 1989.
Gallaher, 1987, "Detection of a Fusion . . . " Cell, 50: 327-328.
Fox, "No Winners Against AIDS" Biotechnology 12:128, 1994.
Cohen, "Jitters Jeopardize AIDS Vaccine . . . " Science 262: 980-981, 1993.
Butini, et al, "Comparative Analysis . . . " J. Cell Biochem. Suppl. 18B, J306, 1994.

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