Synthetic vaccine against urinary infections

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

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530327, 530328, 530806, 530810, 530812, C07K 700, A61K 39108

Patent

active

047405856

ABSTRACT:
A vaccine effective in protecting mammals against urinary tract infections is prepared from synthetic peptides substantially equivalent to short sequences contained in HU849 pilin conjugated to substantially antigenically neutral carriers or from a CNBrII fragment of HU849 pilin.

REFERENCES:
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patent: 4606919 (1986-08-01), Stogkovic et al.
O'Hanley et al, Mannose-Sensitive and Gal-Gal Binding E. coli pili . . . Strains, J Exp Med 158, (1983), pp. 1713-1719.
CA. No. 10686312, Strain-Specific and Common Epitopes of Gono-Coocal pili, Jonathan et al, vol.(101), 1984.
Wilson et al, "The Structure of an Antigenis Determinant in a Protein Cell", vol. 37, 1984, pp. 767-778.
Nunberg et al, "Method to Map Antigenic Determinants Recognized . . . Protein pp 70" PNAS 81, 1984, pp. 3675-3679.
Rothbard et al, Current Communication in Molecular Biology, ed Lauer et al, 1985, pp. 161-168.
Snythetis Peptides as Antigens, ed Porter et al, 1986, pp. 184-193 (varies).

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