Synthetic vaccine against AIDS virus

Details Synthetic vaccine against AIDS virus Synthetic vaccine against AIDS virus

1988-07-21

1991-07-09

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 530326, 530327, 530350, A61K 3900, A61K 3702

Patent

active

050304496

ABSTRACT:
The invention relates to peptide antigens which stimulate helper T lympocytes which specifically recognize HIV envelope protein, thereby enhancing antibody production and cytotoxic T cells to inhibit expression of an infection caused by HIV virus.

REFERENCES:
Palker et al., Proc. Natl. Acad. Sci. U.S.A., vol. 85, pp. 1932-1936, 1988 Mar.
Cease et al., Proc. Natl. Acad. Sci. U.S.A., vol. 84, pp. 4249-4253, Jun. 1987.
Takahashi et al., Proc. Natl. Acad. Sci. U.S.A., pp. 3105-3109, May 1988.
Peter Newmark, Nature, vol. 324, pp. 304-305, Nov. 1986.
Palker et al. "Type Specific Neutralization of HIV With Antibodies to Env-Encoded Synthetic Peptides", Proc. Natl. Acad. Sci, U.S.A., vol. 85, pp. 1932-1936, Mar. 1988.
Takahashi et al., "An Immunodominant Epitope of the HIV Envelope Glycoprotein gp160 recognized by Class I MHC Molecules-Restricted Murine CTL", Proc. Natl. Acad. Sci., vol. 58, pp.3105-3109, May 1988.
Cease et al., "Helper T-cell Antigenic Site Identification in AIDS virus gp 120 Envelope Protein and Induction of Immunity in Mice to the Native Protein Using a 16-Residue Synthetic Peptide," Proc. Natl. Acad. Sci., vol. 84, pp. 4249-423, Jun. 1987.
Clerici et al., 1989, Nature, 339: 383-385.

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