Synthetic TRNAS

Details Synthetic TRNAS Synthetic TRNAS

1992-07-14

1994-10-25

Wax, Robert A.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

536 231, 935 3, 935 17, C12N 1511, C07H 2104

Patent

active

053588622

ABSTRACT:
Synthetic tRNAs are produced from tRNA.sup.Cys (AAA), tRNA.sup.Ser (AAA), tRNA.sub.e.sup.Ala (AAA), and tRNA.sub.i.sup.Ala (AAA) genes. Polyuridylic acid-dependent syntheses of polypeptides were carried out in vitro on E. coli ribosomes using the synthetic tRNAs.

REFERENCES:
Schulman (1991) Progress in Nucleic Acid Research and Molecular Biology 2:23-87.
Normanly et al., (1989) Annual Review of Biochemistry 58:1029-49.
Bull et al., (1987) DNA 6:353-362.
Bruce et al., (1982) Biochemistry 21:3921-3926.
Gavini et al., (1992) J. Biological Chemistry 266:2240-2243.
E. Katchalski et al., "Synthesis & Chemical Properties of poly-.alpha.-amino acids"in Advances in Protein Chemistry 13 (1958) pp. 243-292.

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