Synthetic triple helix-forming compound precursors

Details Synthetic triple helix-forming compound precursors Synthetic triple helix-forming compound precursors

1995-02-01

1998-12-01

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2713, 544279, 544283, C07H 706, C07D23972, C07D47100, C07D48700

Patent

active

058441107

ABSTRACT:
The present invention discloses novel monomeric compositions which are substituted quinoline- or quinazoline-based structures capable of hydrogen bonding specifically with interstrand purine-pyrimidine base pairs in a double-stranded Watson-Crick DNA molecule. Furthermore, the novel monomeric compounds of the present invention are capable of being assembled in specific sequences into oligomers capable of binding with sequence specificity to duplex DNA via a triple helix motif.

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