Synthetic tridecapeptide [Gln.sup.4 ]-neurotensin having hormona

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424177, C07C10352

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active

041103211

ABSTRACT:
A tridecapeptide, [Gln.sup.4 ]-neurotensin, has been effectively synthesized and which has the sequence (pyro)glutamyl-leucyl-tyrosyl-glutaminyl-asparaginyl-lysyl-prolyl-arginyl- arginyl-prolyl-tyrosinyl-isoleucyl-leucyl-acid. [Gln.sup.4 ]-neurotensin has the unique hormonal activities and chemical structure of the native hormone in bovine hypothalamic tissue.

REFERENCES:
R. Carraway et al., The Journal of Biological Chemistry 250, 1975, pp. 1907-1918
R. Carraway et al., The Journal of Biological Chemistry 248, 1973, pp. 6854-6861.

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