Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-05-30
2006-05-30
Li, Ruixiang (Department: 1646)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S252300, C435S254110, C435S254200, C435S320100, C536S023400, C530S350000, C514S002600, C514S013800
Reexamination Certificate
active
07052906
ABSTRACT:
The invention relates to nucleic acids encoding a synthetic transmembrane region as well as to membrane associated proteins containing these synthetic transmembrane regions. The design of the synthetic transmembrane region allows various properties of a protein, such as its level of expression, and relative response to ligand binding to be tailored as required for a specific purpose.
REFERENCES:
patent: WO 96/23881 (1996-08-01), None
patent: WO 96 23881 (1996-08-01), None
patent: WO 97/23613 (1997-07-01), None
patent: WO 97 23613 (1997-07-01), None
patent: WO 99/57268 (1999-11-01), None
patent: WO 00/63372 (2000-10-01), None
Marra et al. EMBL database, Accession No: AA444968, Jun. 3, 1997.
Fire et al. A modular set of lac Z fusion vectors for studying gene expression iCaenorhabditis elegans. Gene 93:189-198, 1990.
Killian et al. Induction of nonbilayer structures in diacylphosphatidylcholine model membranes by transmembrane alpha-helical peptides: importance of hydrophobic mismatch and proposed role of Tryptophans. Biochemistry 35: 1037-1045, 1996.
Eshhar, Z. Cancer Immunol. Immunother. 45:131-136, 1997.
Sean Munro Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention. EMBO 10:3577-3588, 1991.
Finney et al. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J. Immunol. 161:2791-2797, 1998.
A. Aruffo, et al., “Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system”,PNAS, USA1987, 84, 8573-8577.
Bebbington, C.R. “Xpression of antibody genes in nonlymphoid mammalian cells”Methods: A companion to methods in Enzymology,1991, 2,136-145.
Eshhar, Z., “Tumor-specific T-bodies: towards clinical application”,Cancer Immunol. Immunother, 1997, 45, 131-136.
Fire, A. et al., “A modular set of lacZ fusion vectors for studying gene expression inCaenorhabditis elagans”, Gene, 1990, 93, 189-198.
Honsho, M. et al., “Retention of cytochrome b5 in the endoplasmic reticulum is transmembrane and luminal domain-dependent”,The Journal of Bilogical Chemistry, 1998, 273(33), 20860-20866.
Kuster, H. et al., “Characterization and expression of the gene for the human Fc receptor . . . subunit”,J. Biol. Chem, 1990, 265, 6448-6452.
Moingeon, P. et al., “Human natural killercells andmature T lymphocytes express identical CD3 subunits as defined by cDNA cloning and sequence analysis”,Eur J. Immunol, 1990, 20, 1741-1745.
Munro, S., “Sequences within and adjacent to the transmembrane segment of α-2, 6-sialyltransferase specify Golgi retention”,The EMBO Journal, 1991, 10(12), 3577-3588.
Reithmeier, R., “Characterization and modeling of membrane proteins using sequence analysis”,Current Biology, 1995, 5, 491-500.
Weissman, A.M..et al., “Molecular cloning and chromosomal localizationof the human T-cell receptor chain: Distinction from the molecular CD3 complex”,PNAS, 1988, 85, 9709-9713.
Wimley, W.C. et al., “Experimentally determined hydrophobicity scale for proteins at membrane interfaces”,Nature Structural Biology, 1996, 3, 848-8.
Finney Helene Margaret
Griffiths Lawson Alastair David
Celltech R & D Limited
Li Ruixiang
Woodcock & Washburn LLP
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