Synthetic transfection vectors

Details Synthetic transfection vectors Synthetic transfection vectors

1998-04-17

2000-11-28

Campell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424490, 424491, 424493, A61K 4800, A61K 916

Patent

active

061535982

ABSTRACT:
An inorganic particle, to which is bonded a cell binding component and a nucleic acid, is provided for delivery of a nucleic acid to a cell. The disclosed particle acts as a synthetic vector for achieving efficient transfection of associated nucleic acid into a cell.

REFERENCES:
patent: 4452773 (1984-06-01), Molday
Cotten, M. et al. (1992) High-efficiency receptor-mediated delivery of small and large 48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc. Natl. Acad. Sci. USA 89: 6094-6098.
Audesirk, G., Audesirk, T. (1986) Biology: Life on Earth. New York, MacMillan Publishing Company, pp. 66-67.
Wu, G.Y., Wu, C.H. (1988) Receptor-mediated Gene Delivery and Expression in Vivo. The Journal of Biological Chemistry 263(29): 14621-14624.
Walker, P.R. et al. (1989) Effects of Aluminum and Other Cations on the Structure of Brain and Liver Chromatin. Biochemistry 28: 3911-3915.

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