Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-12-09
2000-11-28
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435325, C12Q 168, C12N 510
Patent
active
061533831
ABSTRACT:
Novel synthetic transcriptional modulators having at least one selected ligand linked to at least one transcriptional modulating portion are described. The transcriptional modulators of the present invention can include a ligand linked to a chemical moiety. These transcriptional modulators can be used to selectively control gene expression and to identify components of the transcriptional machinery.
REFERENCES:
patent: 5468614 (1995-11-01), Fields et al.
Arany, Z. et al., "A Family of Transcriptional Adaptor Proteins Targeted by the E1A Oncoprotein," Nature, vol. 374, 81-4 (1995).
Belshaw, P. et al., "Controlling Protein Association and Subcellular Localization with a Synthetic Ligand that Induces Heterodimerization of Proteins," PNAS, vol. 93, 4604-7 (1996).
Bierer, B. et al., "Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand," Science, vol. 250, 556-9 (1990).
Bierer, B. et al., "Two Distinct Signal Transmission Pathways in T Lymphocytes are Inhibited by Complexes Formed Between an Immunophilin and Either FK506 or Rapamycin," PNAS, vol. 87, 9231-5 (1990).
Chen, J. et al., "Identification of an 11-kDa FKBP12-rapamycin-binding Domain Within the 289-kDa FKBP12-rapamycin-associated Protein and Characterization of a Critical Serine Residue," PNAS, vol. 92, 4947-51 (1995).
Clackson, T., "Controlling Mammalian Gene Expression with Small Molecules," Current Opinion in Chemical Biology, vol. 1, 210-8 (1997).
Gallop, M. et al., "Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries," Journal of Medicinal Chemistry, vol. 37, No. 9, 1233-51 (1994).
Gottesfeld, J. et al., "Regulation of Gene Expression by Small Molecules," Nature, vol. 387, 202-5 (1997).
Ho, S. et al., "Dimeric Ligands Define a Role for Transcriptional Activation Domains in Reinitiation," Nature, vol. 382, 822-6 (1996).
Jenster, G. et al., "Steroid Receptor Induction of Gene Transcription: A Two-step Model," PNAS, vol. 94, 7879-84 (1997).
Kay, J., "Structure-function Relationships in the FK506-binding Protein (FKBP) Family of Peptidylprolyl cis-trans Isomerases," Biochem. J., vol. 314, 361-85 (1996).
Ma, J. and Ptashine, M., "A New Class of Yeast Transcriptional Activators," Cell, vol. 51, 113-9 (1987).
Ossareh-Nazari, B. et al., "Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export," Science, vol. 278, 141-4 (1997).
Owen-Hughes, T. and Workman, J., "Remodeling the Chromatin Structure of a Nucleosome Array by Transcription Factor-targeted trans-displacement of Histones," The EMBO Journal, vol. 15, No. 17, 4702-12 (1996).
Rivera, V. et al., "A Humanized System for Pharmacologic Control of Gene Expression," Nature Medicine, vol. 2, No. 9, 1028-32 (1996).
Seipel, K. et al., "Different Activation Domains Stimulate Transcription from Remote (`enhancer`) and Proximal (`promoter`) Positions," The EMBO Journal, vol. 11, No. 13, 4961-8 (1992).
Silverman, N. et al., "Yeast ADA2 Protein Binds to the VP16 Protein Activation Domain and Activates Transcription," PNAS, vol. 91, 11665-8 (1994).
Spencer, D. et al., "Controlling Signal Transduction with Synthetic Ligands," Science, vol. 262, 1019-24 (1993).
Stade, K. et al., "Exportin 1 (Crm 1p) is an Essential Nuclear Export Factor," Cell, vol. 90, 1041-50 (1997).
Standaert, R. et al., "Molecular Cloning and Overepression of the Human FK506-binding Protein FKBP," Nature, vol. 346, 671-4 (1990).
Steger, D. and Workman, J., "Remodeling Chromatin Structures for Transcription: What Happens to the Histones?" BioEssays, vol. 18, No. 11, 875-84 (1996).
Tijan, R. and Maniatis, T., "Transcriptional Activation: A Complex Puzzle with Few Easy Pieces," Cell, vol. 77, 5-8 (1994).
Wermuth, J. et al., "Stereoisomerism and Biological Activity of the Selective and Superactive .alpha..sub.v .beta..sub.3 Integrin Inhibitor Cyclo-(RGDfV-) and its Retro-Inverso Peptide," J. Am. Chem. Soc., vol. 119, No. 6, 1328-35 (1997).
Wolff, B. et al., "Leptomycin B is an Inhibitor of Nuclear Export: Inhibition of Nucleo-cytoplasmic Translocation of the Human Immunodeficiency Virus Type 1 (HIV-1) Rev Protein and Rev-dependent mRNA," Chemistry and Biology, vol. 4, 139-47 (1997).
Nyanguile Origene
Verdine Gregory L.
Clauss Isabelle M.
Schwartzman Robert A.
Vincent Matthew P.
LandOfFree
Synthetic transcriptional modulators and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthetic transcriptional modulators and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic transcriptional modulators and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1723769