Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Reexamination Certificate
2004-04-02
2008-03-11
Seaman, Margaret D. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
C560S262000, C568S011000
Reexamination Certificate
active
07342124
ABSTRACT:
Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
REFERENCES:
patent: 5010099 (1991-04-01), Gunasekera et al.
patent: 5681847 (1997-10-01), Longley et al.
patent: 5789605 (1998-08-01), Smith, III et al.
patent: 6031133 (2000-02-01), Smith, III et al.
patent: 6096904 (2000-08-01), Smith et al.
patent: 6242616 (2001-06-01), Smith, III et al.
patent: 2002/0103387 (2002-08-01), Smith, III et al.
patent: WO 03/013502 (2003-02-01), None
Smith et al. Organic Letters, 1999, vol. 1, pp. 1823-1826.
Harried, S.S., et al., “Total synthesis of (-)-discodermolide: an application of a chelation-controlled alkylation reaction,”J. Org. Chem., 1997, 62, 6098-6099.
Hodges, J.C., et al., “Reactions of lithiooxazole,”Am. Chem. Soc., 1991, 449-452.
Hung, D.T., et al., “Syntheses of discodermolides useful for investigating microtubule binding and stabilization,”J. Am. Chem. Soc., 1996, 118, 11054-11080.
Smith, A.B., III, et al., “Total synthesis of (-)-discodermolide,”J. Am. Chem. Soc., 1995, 117, 12011-12012.
Greene, et al.,Protective Groups in Organic Synthesis, 3rdEd., John Wiley & Sons, NY, 1999.
Gunasekera, S.P., et al., “Discodermolide: a new bioactive polyhydroxylated lactone from the marine spongediscodermia dissolute, ” J. Org. Chem., 1990, 55, 4912-4915 (original article) (correction published in journal at:J. Org. Chem., 1991, 56, p. 1346).
Hung, D.T., et al., “(+)-discodermolide binds to microtubules in stoichiometric ratio to tubulin dimmers, blocks taxol binding and results in mitotic arrest,”Chem.&Biol., 1996, 3, 287-293.
Hung, D.T., et al., “Distinct binding and cellular properties of synthetic (+)- and (−)- discodermolides,”Chem.&Biol., 1994, 1, 67-71.
Longley, R.E., et al., “Discodermolide—a new, marine-derived immunosuppressive compound,”Transplantation, 1991, 52(4), 650-656.
Longley, R.E., et al., “Discodermoldine—a new, marine-derived immunosuppressive compound,”Transplantation, 1991, 52(4), 656-661.
Longley, R.E., et al., “Immunosuppression by discodermolide,”Ann. N.Y. Acad. Sci., 1993, 696, 94-107.
Martello, L.A., et al. “The relationship between taxol and (+)-discodermolide: synthetic analgs and modeling studies,”Chem.&Biol., 2001, 8, 843-855.
Nerenberg, J.B., et al., “Total synthesis of the immunosuppressive agent,”J. Am. Chem. Soc., 1993, 115, 12621-12622.
Smith, A.B., et al., “A practical improvement, enhancing the large-scale synthesis of (+)-discodermolide: a third-generation approach,”Org. Lett., 2003, 5(23), 4405-4408.
ter Haar, E., et al., “Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol,”Biochemistry, 1996, 35, 243-250.
Burlingame Mark
Freeze Brian Scott
Hirose Tomoyasu
Martin Ignació Brouard
Myles David C.
Kosan Biosciences, Inc.
Rahmani Niloofar
Seaman Margaret D.
The Trustees Of The University Of Pennsylvania
Woodcock & Washburn LLP
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