Synthetic sterically-constrained pepzyme catalysts modeled on ly

Details Synthetic sterically-constrained pepzyme catalysts modeled on ly Synthetic sterically-constrained pepzyme catalysts modeled on ly

1995-06-05

1998-06-02

Weber, Jon P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

4351885, 435199, 435206, 530317, 530324, C12N 900, C12N 922, C12N 936, C07K 1400

Patent

active

057598347

ABSTRACT:
Pepzymes, chemically synthesized cyclic peptides, modeled on lysozyme and ribonuclease have been prepared which efficiently catalyze the same reaction as the native enzyme being modeled. The synthetic pepzymes have a sequence of amino acids which is substantially shorter than the naturally occurring enzymes. Methods of producing these pepzymes are described. Pepzymes may be useful catalysts under conditions where the native enzymes are inactive.

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