Synthetic route to ABCD-porphyrins

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S402000, C548S419000, C548S518000

Reexamination Certificate

active

07994312

ABSTRACT:
A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under basic conditions to produce the metalloporphyrin. Products produced by such methods and intermediates useful for carrying out such methods are also described.

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Dogutan et al. “Investigation of the Scope of a New Route to ABCD-Bilanes and ABCD-Porphyrins” Journal of Organic Chemistry, 2008, vol. 73, No. 17, pp. 6728-6742.
Strachan J-P et al. Rational synthesis of meso-substituted chlorin building blocks. J. Org. Chem. (2000), vol. 65, pp. 3160-3172.
Rao, P D et al. Rational syntheses of porphyrins bearing up to four different meso substituents. J. Org. Chem. (2000), vol. 65, pp. 7323-7344.
Zaidi S H H et al. Investigation of streamlined syntheses of porphyrins bearing distinct meso substituents. Organic Process Research & Development (2006), vol. 10, pp. 118-134.
International Search Report and Written Opinion, PCT/US08/01774, issued Jun. 13, 2008.
International Preliminary Report on Patentability, PCT/US08/01774, issued Aug. 19, 2009.

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