Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1992-08-10
1995-08-29
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4241851, 4242601, 530300, 530327, 530350, A61K 3902, A61K 3938, A61K 3810, C07K 100
Patent
active
054458188
ABSTRACT:
Treatment and diagnosis of P. aeruginosa infection or colonization is achieved in accordance with this invention by the discovery of a polypeptide which is smaller than the naturally occurring P. aeruginosa pillin protein. The pure polypeptide comprises at least one amino acid residue sequence containing about twelve amino acid residues and up to about twenty amino acid residues that define a sequence capable of immunologically mimicking an antigenic determinant cite of P. aeruginosa pilin. This amino acid residue sequence can repeat as a unit one or more times in the same polypeptide molecule. More than one of such repeating units and more than one repeating unit of the same type can be present in a single polypeptide molecule. The polypeptides act an antigens or immunogens and antibodies may be raised to the immunogens and a vaccine prepared suitable for the prevention of P. aeruginosa infection.
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Doig Peter C.
Hodges Robert S.
Irvin Randall T.
Lee Kok K.
Paranchych William
Dehlinger Peter J.
Sidberry Hazel F.
Stratford Carol A.
The Governors of the University of Alberta
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