Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-08-25
1997-03-18
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242421, 4242601, 530326, 530327, A61K 3902, A61K 39108, A61K 3810
Patent
active
056120362
ABSTRACT:
Treatment and diagnosis of P. aeruginosa infection or colonization is achieved in accordance with this invention by the discovery of a polypeptide which is smaller than the naturally occurring P. aeruginosa pillin protein. The pure polypeptide comprises at least one amino acid residue sequence containing about twelve amino acid residues and up to about twenty amino acid residues that define a sequence capable of immunologically mimicking an antigenic determinant cite of P. aeruginosa pilin. This amino acid residue sequence can repeat as a unit one or more times in the same polypeptide molecule. More than one of such repeating units and more than one repeating unit of the same type can be present in a single polypeptide molecule. The polypeptides act an antigens or immunogens and antibodies may be raised to the immunogens and a vaccine prepared suitable for the prevention of P. aeruginosa infection.
REFERENCES:
patent: 4443549 (1984-04-01), Sadowski
patent: 4702911 (1987-10-01), McMichael
patent: 5494672 (1996-02-01), Hodges et al.
Beachey, E. H., "Bacterial Adherence: Adhesion-Receptor Interactions Mediating the Attachment of Bacteria to Mucosal Surfaces," J. Infect. Dis. 143(3): 325-345 (1981).
Doig, P., et al., "Role of Pili in Adhesion of Pseudomonas aeruginosa to Human Respiratory Epithelial Cells," Infect. and Immun. 56(6):1641-1646 (1988).
Doig, P., et al., "Characterization of the Binding of Pseudomonas aeruginosa Alignate to Human Epithelial Cells," Infect. and Immun. 55(6):1517-1522 (1987).
Lee, et al., "Immunological Studies of the Disulfide Bridge Region of Pseudomonas aeruginosa PAK and PAO Pilins, Using Anti-PAK Pilins and Antipeptide Antibodies," Infect. & Immun. 57:520-526 (1989).
Marcus, H., et al., "Quantitation of Adherence of Mucoid and Nonmucoid Pseudomonas aeruginosa to Hamster Tracheal Epithelium," Infect. and Immun. 47(3):723-729 (1985).
McEachran, D., et al., "Adhesion of Pseudomonas aeruginosa to Human Epithelial Buccal Cells: Evidence for Two Classes of Receptors," Can. J. Microbiol. 31:563-569 (1985).
McEachran, D., et al., "A New Method for the Irreversible Attachment of Cells or Proteins to Polystyrene Tissue Culture Plates for Use in the Study of Bacterial Adhesion" J. Microbiol. Meth. 5:99-111 (1986).
Paranchych, et al., "Pseudomonas Pili: Studies of Antigenic Determinants and Mammalian Cell Receptors," Antibiot. Chemother. 36:49-57 (1985).
Paranchych, et al., "Fimbriae (Pili): Molecular Basis of Pseudomonas Aeruginosa Adherance," Clinical & Invest. Med. 9:113-118 (1986).
Parker, et al., "New Hydrophilicity Scale Derived from High-Performance Liquid Chromatography Peptide Retention Data: Correlation of Predicted Surface Residues with Antigenicity and X-ray-Derived Accesible Sites," Biochem. 25:5425-5432 (1986).
Pasloske, B, et al. "Two Unusual Pilin Sequences from Different Isolates of Pseudomonas aeruginosa," J. Bacteriol. 170(8):3738-3741 (1988).
Pier, et al., "A Murine Model of Chronic Mucosal Colonization by Pseudomonas aeruginosa," Infect. & Immun. 60:4768-4776 (1992).
Ramphal, R., et al., "Role of Pili in the Adherence of Pseudomonas aeruginosa to Injured Trachael Epithelium," Infect. and Immun. 44:38-40 (1984).
Ramphal, R., et al., "Pseudomonas aeruginosa Adhesions for Tracheobronchial Mucin," Infect and Immun. 47:1-4 (1985).
Sastry, et al., "Comparative Studies of the Amino Acid and Nucleotide Sequences of Pilin Derived from Pseudomonas aeruginosa PAK and PAO," J. Bacteriol. 164:571-577 (1985).
Sastry, et al., "Studies on the Primary Structure and Antigenic Determinants of Pilin Isolated from Pseudomonas aeruginosa K," Can. J. Cell. Biol. 63:284-291 (1985).
Stryndaka, N. C. J., et al., "Use of Synthetic Peptides to Map Antigenic Determinants of Glycoprotein D of Herpes Simplex Virus," J. Virol. 62:3474-3483 (1988).
Tramont, et al., "Parenteral Gonococcal Pilus Vaccine," The Pathogenic Neisseriae pp. 316-321 (1984).
Watts, et al., "Mapping of the Antigenic Determinants of Pseudomonas aeruginosa PAK Polar Pili," Infect and Immun. 42(1):113-121 (1983).
Woods, et al., "Role of Pili in the Adherence of Pseudomonas aeruginosa to Mammalian Buccal Epithelium Cells," Infect. and Immun. 29:1146-1151 (1980) .
Doig Peter C.
Hodges Robert S.
Irvin Randall T.
Lee Kok K.
Paranchych William
Dehlinger Peter J.
Nucker Christine M.
Prickril Benet
Stratford Carol A.
The Governors of the University of Alberta
LandOfFree
Synthetic Pseudomonas aeruginosa pilin peptide vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthetic Pseudomonas aeruginosa pilin peptide vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic Pseudomonas aeruginosa pilin peptide vaccine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1704174