Synthetic pseudoceramide and cosmetic compositions thereof

Details Synthetic pseudoceramide and cosmetic compositions thereof Synthetic pseudoceramide and cosmetic compositions thereof

1992-01-14

1993-04-27

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 59, 424 61, 424 69, 424 70, 424501, 514 24, 514 25, 514119, A61K 700, A61K 748, A61K 21685

Patent

active

052060209

ABSTRACT:
Novel pseudoceramides are compounds with a general structure (2): ##STR1## In this formula a is 0 or 1, b is 0 or 1 but if a is 0, b is also 0 and R has 1 to 8 carbon atoms. The substituents R and R.sup.1 are a range of substituted or unsubstituted aliphatic hydrocarbon substituents. R.sup.2 is hydrogen, a sugar residue, a sulphate residue or a phosphate residue. R.sup.3 is hydrogen or a fairly short chain hydrocarbon substituent which in turn may be substituted. All of the substituents R--R.sup.3 are more fully defined in claim 1. These novel compounds are effective to improve water barrier function of the stratum corneum. They may be incorporated into compositions for topical application to human skin, hair and nails. A synthetic route for obtaining the novel compounds is described.

REFERENCES:
Imokawa et al. J. Soc. Cosmet. Chem. 40,273-285 Sep./Oct. 1989.
Meyer et al. J. Med. Chem. 1991, 34, 1377-1383.
European Search Report completed Apr. 22, 1992.
Chemical Abstracts, vol. 111, No. 12, Sep. 18, 1989, K. Tsubone "2-(2-Hydroxy-N-alkyl)acyloxypropylamion) ethylphosphate ester salts for the manufacture of pharmaceutical, cosmetic and agrochemical liposomes" p. 354, Abstract No. 102703j.
J. Invest. Derm., Fulmer & Kramer, (1986), 86, pp. 598-602.
Tupker R. A. et al, Acta Derm. Venereol. Stockh (1990), 70, pp. 1-5.

Affiliated with

Also associated with

Rating

Synthetic pseudoceramide and cosmetic compositions thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic pseudoceramide and cosmetic compositions thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic pseudoceramide and cosmetic compositions thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2325471