Synthetic prothrombin peptides and antibodies directed against t

Details Synthetic prothrombin peptides and antibodies directed against t Synthetic prothrombin peptides and antibodies directed against t

1988-08-17

1991-12-10

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, 530387, 530806, C07K 706, C07K 708, C07K 710, C07K 1702

Patent

active

050719548

ABSTRACT:
The invention relates to synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic, to the use thereof for the immunization of an animal and for the purification of specific antibodies, to antibodies against these peptides, and to the use of the antibodies for the determination of the fragments F.sub.2 /F.sub.1+2.

REFERENCES:
Textbook of Immunology, James T. Barrett, pp. 72-75, 1978.
Walz, D. A., "Amino Acid Sequence of Prothrombin Fragments 1 and 2", Proc. Natl. Acad. Sci. U.S.A., vol. 74(5), pp. 1969-1972.
Lau et al., "The Isolation and Characterization of a Specific Antibody Population . . . ", J. Biological Chemistry V 254 (18), Sep. 25, 1979.

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