Synthetic process for the preparation of tricyclic and tetracycl

Details Synthetic process for the preparation of tricyclic and tetracycl Synthetic process for the preparation of tricyclic and tetracycl

1996-12-19

1998-06-02

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

057602522

ABSTRACT:
Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.

REFERENCES:
patent: Re34277 (1993-06-01), Denis et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 5015744 (1991-05-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5229526 (1993-07-01), Holton et al.
patent: 5248796 (1993-09-01), Chen et al.
patent: 5254703 (1993-10-01), Holton
patent: 5274137 (1993-12-01), Nicolaou et al.
patent: 5290957 (1994-03-01), Correa et al.
patent: 5292921 (1994-03-01), Correa et al.
patent: 5416225 (1995-05-01), Danishefsky et al.
patent: 5461169 (1995-10-01), Nicolaou et al.
patent: 5481007 (1996-01-01), Nicolaou et al.
patent: 5488116 (1996-01-01), Danishefsky et al.
patent: 5508447 (1996-04-01), Magnus
patent: 5527924 (1996-06-01), Danishefsky et al.
patent: 5597931 (1997-01-01), Danishefsky et al.
Klein Synthesis of 9-Dihydrotaxol: A Novel Bioactive Taxol Tetrahedron Letters, vol. 34, No. 13 (1993) pp. 2047-2050.
Holton et al. "A Novel Lanthanide-Induced Rearrangement" Journal of Organic Chemistry, vol. 53 (1988) pp. 5981-5983.
Holton "Synthesis of the Taxane Ring System" Journal of American Chemical Society, vol. 106 (1984) p. 5731.
Holton et al., "Synthesis of Taxusin" Journal of American Chemical Society, vol. 110 (1988) p. 6558.
Hanessian et al. "A Practical Synthesis of 2-Deoxy Aldonolactones via a SMI.sub.2 -Mediated .alpha.-Deoxygenation Reaction" Tetrahedron Letters, vol. 33, No. 5 (1992) pp. 573-576.
Farina et al., "The Chemistry of Taxanes: Unexpected Rearrangement with Bu.sub.3 SnOMe/LiCl" Tetrahedron Letters, vol. 33, No. 28 (1992) pp. 3979-3982.
Chen et al., "Taxol Structure-Activity Relationships: Synthesis and Biological Evaluation of 2-Deoxytaxol" Tetrahedron Letters, vol. 34, No. 20 (1993) pp. 3205-3206.
Chen et al., "Synthesis of 7-Deoxy-and 7,10-Dideoxytaxol via Radical Intermediates" Journal of Organic Chemistry, vol. 58 (1993) pp. 5028-5029.
Chaudhary et al. "Synthesis of 10-Deacetoxytaxol and 10-Deoxytaxotere" Tetrahedron Letters, vol. 34, No. 31 (1993) pp. 4921-4924.
Samaranayake et al. "Modified Taxols. 5. Reaction of Taxol with Electrophilic Reagents and Preparation of a Rearranged Taxol Derivatives with Tubulin Assembly Activity" Journal of Organic Chemistry, vol. 56 (1991) pp. 5114-5119.
Borman, "Total Synthesis of Anticancer Agent Taxol Achieved by Two Different Routes" C & EN (Feb. 21, 1994) pp. 32-34.
Kingston et al. "Progress in the Chemistry of Organic Natural Products 61", pp. 1-3 and 81-143, 1993.
Holton et al. "First Total Synthesis of Taxol. 1. Functionalization of the B Ring" Journal of American Chemical Society, vol. 116 No. 4 (1994) pp. 1597-1598.
Holton et al, "First Total Synthesis of Taxol. 2. Completion of the C and D Rings" Journal of American Chemical Society, vol. 116, No. 4, (1994) pp. 1599-1600.
Nicolaou et al. "A Convergent Strategy Towards Taxol. A Facile Enantioselective entry Into a Fully Functionalized Ring A System" Journal of American Chemical Society, Chem. Commun., No. 16, (Aug. 1992) pp. 1117-1120.
G. Georg et al. "ACS Symposium Series 583 -Taxane Anticancer Agents, Basic Science and Current Status" 207th National Meeting of the Am. Chem. Soc., San Diego, CA (Mar. 12-17, 1994).

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