Synthetic process for the preparation of taxol and other tricycl

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549229, 549230, 549299, 549300, 549510, 549511, C07D30514, C07D30793, C07D31770

Patent

active

054059720

ABSTRACT:
Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.

REFERENCES:
patent: Re34277 (1993-08-01), Denis et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 5015744 (1991-05-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5229526 (1993-07-01), Holton
patent: 5248796 (1993-09-01), Chen et al.
patent: 5254703 (1993-10-01), Holton
patent: 5274137 (1993-12-01), Nicolaou et al.
patent: 5290957 (1994-03-01), Correa et al.
patent: 5292921 (1994-03-01), Correa et al.
L. Klein "Synthesis of 9-Dihydrotaxdol: A Novel Bioactive Taxol" Tetrahedron Letters, vol. 34, No. 13, pp. 2047-2050 (1993).
R. Holton et al. "A Novel Lanthanide-Induced Rearrangement" J. Org. Chem., vol. 53, pp. 5981-5983 (1988).
R. Holton "Synthesis of the Taxane Ring System" Journal of Am. Chem. Soc., vol. 106, pp. 5731 (1984).
R. Holton et al. "A Synthesis of Taxusin" Journal of Am. Chem. Soc., vol. 110, pp. 6558 (1988).
Hanessian et al. "A Practical Synthesis of 2-Deoxy Aldono-lactones via a SMI.sub.2 -Mediated .alpha.-Deoxygenation Reaction" Tetrahedron Letters, vol. 33, No. 5, pp. 573-576 (1992).
V. Farina et al. "The Chemistry of Taxanes: Unexpected Re-arrangement of Baccatin III During Chemoselective Debenzoylation with Bu.sub.3 SnOMe/LiCl" Tetrahedron Letters, vol. 33, No. 28, pp. 3979-3982 (1992).
S. Chen et al. "Taxol Structure-Activity Relationships: Synthesis and Biological Evaluation of 2-Deoxytaxol" Tetrahedron Letters, vol. 34, No. 209, pp. 3205-3206 (1993).
S. Chen et al., "Synthesis of 7-Deoxy- an 7,10-Dideoxytaxol via Radical Intermediates" J. Org. Chem. vol. 58, pp. 5028-5029, (1993).
A. Chaudhary et al. "Synthesis of 10-Deacetoxytaxol and 10-Deoxytaxotere" Tetrahedron Letters vol. 34, No. 31, pp. 4921-4924 (1993).
G. Samaranayake et al. "Modified Taxols. 5. Reaction of Taxol with Electrophilic Reagents and Preparation of a Rearranged Taxol Derivatives with Tubulin Assembly Activity" J. Org. Chem., vol. 56, pp. 5114-5119 (1991).
S. Borman "Total Synthesis of Anticancer Agent Taxol Achieved by Two Different Routes" C & EN pp. 32-34 (Feb. 21, 1994).
D. Kingston et al., "Progress in the Chemistry of Organic Natural Products 61" pp. 1-3 and 81-143, 1993.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Synthetic process for the preparation of taxol and other tricycl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic process for the preparation of taxol and other tricycl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic process for the preparation of taxol and other tricycl will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1539620

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.