Synthetic process for the manufacture of an ecteinaschidin...

Details Synthetic process for the manufacture of an ecteinaschidin... Synthetic process for the manufacture of an ecteinaschidin...

2005-10-11

2008-09-02

Tucker, Zachary C (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07420051

ABSTRACT:
Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxyl, di-6,8-en-5-one fused ring compound. After formation of the 1,4 brige, C-18 protection is removed before spiroamine introduction.

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Lichter,

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