Synthetic process for anticancer drug fluorapacin and...

Details Synthetic process for anticancer drug fluorapacin and... Synthetic process for anticancer drug fluorapacin and...

2009-03-27

2010-12-14

Sullivan, Daniel M (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfur containing

Reexamination Certificate

active

07851657

ABSTRACT:
The invention provides a synthetic and manufacturing process for the preparation of the anticancer drug, fluorapacin, bis(4-fluorobenzyl)trisulfide, and related trisulfide derivatives on large scale. Also provided are processes for the purification and isolation of fluorapacin having high purity and improved stability.

REFERENCES:
patent: 2005/0261321 (2005-11-01), Xu et al.
patent: WO-2005/112933 (2005-12-01), None
An et al., {Synthesis and anti-tumor evaluation of new trisulfide derivatives, Bioorganic & Medicinal Chemistry Letters (2006), 16(18), 4826-4829}.
Stensaas et al., {Competitive oxidations of dibenzyl trisulfide vs. substituted aryl polysulfides, Journal of Sulfur Chemistry (2008), 29(3-4), 433-443}.
Wong et al., {Desulfurization of bibenzyl trisulfide by [CpMo(CO)3]2: Formation and isolation of thiolato-bridged dimolybdenum complexes of [CpMo(CO)2(SBz)]2, [CpMo(CO)(SBz)]2S and [CpMo(SBz)S]2 (Cp = (h5-C5H5), Bz = PhCH2-). Crystal structures of two polymorphs of [CpMo(SBz)S]2, Inorganica Chimica Acta (2007), 360(9), 3113-3118}.
An et al., Bioorg. Med. Chem. Lett. (2006) 16:4826-4829.
An et al., AAPS PharmSciTech (2008) 9:551-556.
Banerji and Kalena, Tetrahedron Lett. (1980) 21:3003-3004.
Derbesy and Harpp, Tetrahedron Lett. (1994) 35:5381-5384.
Harpp et al., Tetrahedron Lett. (1970) 3551-3554.
Harpp et al., Tetrahedron Lett. (1976) 3001-3004.
Mata-Greenwood et al., Anticancer Res. (2001) 21:1763-1770.
Rosner et al., Biochim. Biophys. Acta (2001) 1540:166-177.
Sinha et al., Organometallics (2001) 20:157-162.

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