Synthetic preparation of amylin and amylin analogues

Details Synthetic preparation of amylin and amylin analogues Synthetic preparation of amylin and amylin analogues

1993-07-08

1995-06-13

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530307, 530327, A61K 3800, A61K 3823, A61K 3700, C07K 1400

Patent

active

054243947

ABSTRACT:
Synthetic amylin and amylin analogs which have high biological activity and which are substantially free from deletion peptides and other contaminating peptides are provided. Also provided are methods for the solid phase peptide synthesis of amylin and amylin analogs.

REFERENCES:
patent: 4743677 (1988-05-01), Noda et al.
patent: 4992530 (1991-02-01), Morita et al.
patent: 5367052 (1994-11-01), Cooper et al.
Leighton & Cooper, Nature 335:632-635 (1988).
Leighton et al., Diabetologia 31:513A (1988).
Fujii et al., Chem. Pharm. Bull. 35(6):2339-2347 (1987).
Fujii et al., Chem. Pharm. Bull. 35(12):4769-4776 (1987).
Cooper et al. PNAS USA vol. 85, 7763-7766 (Oct. 1988).
Hiskey, The Peptides, vol. 3 (Gross & Meinhofer ed. 1981) pp. 137-167.

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