Synthetic polystyrene resin and its use in solid phase peptide s

Details Synthetic polystyrene resin and its use in solid phase peptide s Synthetic polystyrene resin and its use in solid phase peptide s

1988-03-21

1989-08-22

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 5411, 530334, C08L 8900, C07C10352

Patent

active

048597368

ABSTRACT:
A synthetic resin based on a polystyrene that can be used as a support for solid phase peptide synthesis and that has been cross-linked with from 0 to 5 mol % of divinyl benzene, characterized in that it has been substituted at benzene rings of its skeletal structure by groups of the formula ##STR1## in which X represents --O-- or --NH-- and R represents C.sub.1 -C.sub.4 -alkyl, as a support renders possible the solid phase synthesis of peptides and peptide amides that are, if desired, protected at the N-terminal and/or at other functional groups. The resin is manufactured by reaction of a customary chloromethylated polystyrene resin with an alkali metal salt of the corresponding 4-hydroxybenzophenone and subsequent reduction of the carbonyl group and, optionally, amination.

REFERENCES:
patent: 4569967 (1986-02-01), Kornreich et al.
patent: 4731412 (1988-03-01), Kaiser et al.
Southard et al., Tetrahedron, vol. 27, pp. 2701-2703 (1971).
Atherton et al., Proceedings of the 7th American Peptide Symposium (1981) pp. 163-175.
Rink, Tetrahedron Letters, vol. 28, No. 33, pp. 3787-3790 (1987).
Rink, Peptide Chemistry, 1987, Protein Research Foundation, Osaka (1988) pp. 279-282.
Penke et al., J. Org. Chem., vol. 52, No. 7, pp. 1197-2000 (1987).
Breipohl et al., Tetrahedron Letters, vol. 28, No. 46, pp. 5651-5654 (1987).

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