Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Patent
1985-08-12
1987-08-25
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
530326, 530325, 530324, C07C 708, C07C 710
Patent
active
046893970
ABSTRACT:
Antigens, immunogens, inocula, antibodies, diagnostic methods and systems relating to tuberculous mycobacteria are disclosed. Each of the compounds, compositions, methods or systems contains a synthetic polypeptide having about 13 or 14 to about 40 residues, or an antibody containing site that immunoreacts with such a polypeptide. The polypeptide includes the thirteen or fourteen amino acid reside sequence (AlaLysValAsnIleLysProLeuGluAspLysIleCys) or (CysAlaLysValAsnIleLysProLeuGluAspLysIleCys). When linked to a carrier and introduced in an effective amount into a mammalian host, the polypeptide is capable of inducing production of antibodies that immunoreact with an antigen to a tuberculous mycobacterium.
REFERENCES:
patent: 3875002 (1975-04-01), Landi et al.
Can. Journal of Microbiology, vol. 24, No. 9 (1978), 1242-1249.
Infection and Immunity, vol. 50 (1985), No. 3, 614-619.
Infection and Immunity, vol. 27, No. 2 (1980), 344-350.
Infection and Immunity, vol. 30 (1980), No. 3, 686-693.
Minden et al., Infect. Immun., 53:560-564 (1985).
Houghten Richard A.
Minden Percy
Shinnick Thomas M.
Phillips Delbert R.
Scripps Clinic and Research Foundation
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