Synthetic polypeptides corresponding to portions of proteinoids

Details Synthetic polypeptides corresponding to portions of proteinoids Synthetic polypeptides corresponding to portions of proteinoids

1990-02-07

1993-09-07

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 681, 435 691, 435 694, 435 721, 435 792, 436518, G01N 3353, G01N 33543

Patent

active

052427986

ABSTRACT:
Synthetic polypeptides whose sequences correspond substantially to amino acid residue sequences of at least portions of naturally occurring proteinoids translated from brain-specific mRNAs are disclosed as are receptors, methods and diagnostics that utilize those synthetic polypeptides. The synthetic polypeptides have molecular weights less than those of their corresponding proteinoids, and induce the production of antibodies that bind to the naturally occurring proteinoid, or a derivative thereof when bound to a carrier as a conjugate and are introduced into an animal.

REFERENCES:
patent: 3949064 (1976-04-01), Bornstein et al.
patent: 4205057 (1980-05-01), Whitaker
patent: 4237224 (1980-12-01), Cohen et al.
patent: 4342832 (1982-08-01), Goeddel et al.
patent: 4350764 (1982-09-01), Baxter et al.
patent: 4388236 (1983-06-01), Stein
patent: 4401759 (1983-08-01), Rubin et al.
patent: 4416988 (1983-11-01), Rubin
patent: 4430428 (1984-02-01), Fraser et al.
patent: 4677195 (1987-06-01), Hewick et al.
Bloom et al, Proc. Natl. Acad. Sci. USA, vol. 75, No. 3, pp. 1591-1595, Mar. 1978 "Neurons Containing .beta.-Endorphin in Rat Brain Exist Separately From Those Containing Enkephalin".
Sutcliffe et al, Science, vol. 219, 11 Feb. 1983, 660-666, "Antibodies That React With Predetermined Sites On Proteins".
Sutcliffe et al, Proc. Natl. Acad. Sci. USA, vol. 79, pp. 4942-4946, Aug. 1982, "Common `82-Nucleotide Sequence Unique to Brain RNA".
Milner and Sutcliffe, Nucleic Acids Res., 11(16):5497-5520 (1983).
Sutcliffe et al., Cell, 33:671-682 (1983).
Brilliant et al., Mol. Cell Biol., 4:2187 (1984).
Southern, J. Mol. Biol., 98:503-517 (1975).
Gros et al., Molecular Genetic Neuroscience, Schmitt, Bird and Bloom, eds., Raven Press, New York 335-347 (1982).
Cleveland et al., Cell, 20:95-105 (1980).
Green et al., Cell, 28:477-487 (1982).
Naranishi et al., Nature, 278:423-427 (1979).
Amara et al., Nature, 298:240-244 (1982).
Land et al., Nature, 295:299-303 (1982).
Kakidani et al., Nature, 29:245-249 (1982).
Towbin et al., Proc. Natl. Acad. Sci. USA, 76:4350-4354 (1979).
Elder et al., Proc. Natl. Acad. Sci. USA, 79:4540-4544 (1982).
French et al., Regulatory Peptides, 1:127-146 (1980).
Koob et al., Regulatory Peptides, 2:153-163 (1981).
Barnstable, Nature, 286:231-235 (1982).
Thomas, Proc. Natl. Acad. Sci., USA, 77:5201-5205 (1980).
Rigby et al., J. Mol. Biol. 113:237-251 (1977).
Laemmli, Nature, 227:680-682 (1971).
Tanaka et al., J. Bacteriol., 121:354-362 (1975).
Sutcliffe, Nucleic Acid Res., 5:2721-2728 (1978).
Maxam et al., Proc. Natl. Acad. Sci., USA, 74:560-564 (1977).
Bittle et al., Nature, 298:30-33 (1982).
Schibler et al., J. Mol. Biol., 142:93-116 (1980).
Gubler et al., Nature, 295:206-208 (1982).
Rossier, Nature, 298:221-222 (1982).
Marx, Science, 220:395-397 (1983).
Meisenberg et al., Life Sciences, 32:2611-2623 (1983).
Goldstein, Science, 193:1081-1086 (1976).
Kreiner et al., J. Neurosci., 4:2581 (1984).
Schmitt, Neuroscience, 13:991 (1984).
Petrusz et al., Fed. Proc., 44:299 (1985).
Aviv et al., Proc. Natl. Acad. Sci., USA, 69:1409-1412 (1972).
Wickens et al., J. Biol. Chem., 253:2483-2495 (1978).
Gough et al., Biochemistry, 19:2702-2710 (1980).
Jacobsen et al., Eur. J. Biochem., 45:623-627 (1974).
Roychoudary et al., Nucleic Acid Res., 3:865-877 (1976).
Birnboim et al., Nucleic Acid Res., 7:1513 (1979).
Rave et al., Nucleic Acid. Res., 6:3559-3567 (1979).
Denhardt, Biochem. Biophy. Res. Comm., 23:641-646 (1966).
Melli et al., J. Mol. Biol. 93:23-38 (1975).
Derman et al., Cell, 23:731-739 (1981).
Rivier, J. Chromatogr., 202:211-222 (1980).
Arnheiter et al., Nature, 294:278-280 (1981).
Bodor, Science, 214:1370-1372 (1981).
Tachibana et al., Nature, 295:339-340 (1982).
Goedert et al., Develop. Brain Res., 200:127-131 (1985).
Rivier and Vale, Fed. Proc., 44:189-195 (1985).
Herbert, Trends in Biochemical Science, 6:184-188 (1981).
O'Sullivan, Chemical and Engineering News, 26-27, Nov. 15, 1976.
Numa et al., Trends in Biochemical Science, 6:274-277 (1981).
Noda et al., Nature, 297:431-434 (1982).
Comb et al., Nature, 295:663-666 (1982).
Guillemin, Science, 202:390-402 (1978).
Bantle et al., Cell, 8:139-150 (1976).
Hastie et al., Cell, 9:761-774 (1976).

Affiliated with

Also associated with

Rating

Synthetic polypeptides corresponding to portions of proteinoids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic polypeptides corresponding to portions of proteinoids , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic polypeptides corresponding to portions of proteinoids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-486958