Synthetic polypeptides as inhibitors of HIV-1

Details Synthetic polypeptides as inhibitors of HIV-1 Synthetic polypeptides as inhibitors of HIV-1

1995-06-07

1998-11-24

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, 530324, 514 12, C07K 100, C07K 1400, C07K 1700

Patent

active

058408436

ABSTRACT:
A synthetic HIV-1-based polypeptide as well as methods for treating HIV-1 infections are provided herein. The polypeptide of the present invention has an amino acid sequence substantially corresponding to a specified region of the HIV-1.sub.IIIB virus. The polypeptide of the present invention may be administered in effective amounts for preventing and treating HIV-1 infections. The polypeptide is useful for inhibiting the replication of the HIV-1 virus as well as HIV-1-mediated cytopathogenesis and cell fusion at levels which are within acceptable ranges of cytotoxicity.

REFERENCES:
patent: 5444044 (1995-08-01), Jiang et al.
Neurath et al., Virology, vol. 188, pp. 1-13, 1992.
Ratner, et al., "Complete Nucleotide Sequence of the AIDS Virus", Nature, vol. 313, p. 277 (Jan., 1985).
Neurath, et al., "B Cell Epitope Mapping of Human Immunodeficiency Virus Envelope Glycoproteins with Long (19-to 36-) Synthetic Peptides", Journal of General Virology, 71, pp. 85-95 (1990).
Neurath, et al., Virology, vol. 188, pp. 1-13 (1992).

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