Synthetic polypeptide with type IV collagen activity

Details Synthetic polypeptide with type IV collagen activity Synthetic polypeptide with type IV collagen activity

1989-12-14

1992-01-14

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435284, 435285, 435301, 435240243, 530327, 623 1, 623 6, 623 11, 623 22, 623 66, C12M 100, C07K 708, A61F 202, A61F 206

Patent

active

050810316

ABSTRACT:
A polypeptide having the following formula is provided: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met which can bind heparin and promote cellular adhesion. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with a composition including the polypeptide are also provided.

REFERENCES:
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4870160 (1989-09-01), Charonis et al.
patent: 4876332 (1989-10-01), Tsilibary et al.
Koliakos et al., The Binding Of Heparin To Type IV Collagen: Domain Specificity With Identification Of Peptide Sequences From The .alpha.1 . . . , J. Biological Chemistry, vol. 264, No. 4, pp. 2313-2323, Feb. 5, 1989.
Herbst et al., Differential Effects Of Laminin, Intact Type IV Collagen, And Specific Domains Of Type IV Collagen . . . , J. Cell Biology, vol. 106, pp. 1365-1373, Apr. 1988.
Aumailley et al., Attachment Of Cells To Basement Membrane Collagen Type IV, J. Cell Biology, vol. 103, pp. 1569-1576, 1986.
R. Timpl et al., Macromolecular Organization of Type IV Collagen, in New Trends in Basement Membrane Research, Raven Press, NY at 57-67 (1982).
J. Murray et al., J. Cell Biol., 80, 197-202 (1979).
M. Kurkinen et al., J. Biol. Chem., 259, 5915-5922 (1984).
S. Sugrue, J. Biol. Chem., 262, 3338-3343 (1987).
K. Tomaselli et al., J. Cell Biol., 105, 2347-2358 (1987).
J. Oberbaumer et al., Eur. J. Biochem., 147, 217-224 (1985).
T. Pihlajanien et al., J. Biol. Chem., 260, 7681-7687 (1985).
U. Schwarz-Magdolen et al., Febs. Lett., 208, 203-207 (1986).
D. Brazel et al., Eur. J. Biochem., 172, 35-42 (1988).
R. Soininemi et al., Febs. Lett., 225, 188-194 (1987).
D. Brazel et al., Eur. J. Biochem., 168, 529-536 (1987).
G. Muthukamaran et al., J. Biol. Chem., 264, 6310-6317 (1989).
J. Saus et al., J. Biol. Chem., 264, 6318-6324 (1989).
W. Babel et al., Eur. J. Biochem., 143, 545-556 (1984).
E. Tsilibary et al., J. Cell Biol., 103, 2467-2473 (1986).
E. Tsilibary et al., J. Biol. Chem., 263, 19112-19118 (1988).
M. Chelberg et al., Cancer Research, 49, 4796-4802 (1989).

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