Synthetic polypeptide corresponding to a portion of the heat-lab

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

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530325, 530326, 530327, 530328, C07K 706, C07K 708, C07K 710

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active

047586559

ABSTRACT:
Synthetic polypeptides containing about 10 to about 35 amino acid residues corresponding in sequence to the amino acid residue sequence of about position 35 to about position 95 from the amino-terminus of the B-subunit of the heat-labile enterotoxin of Escherichia coli are disclosed along with composite polypeptides containing the polypeptide sequence of the heat-stable Escherichia coli enterotoxin, as are polymers containing the synthetic polypeptide and composite polypeptide as repeating units. The polypeptides are useful as conjugates coupled to a carrier or as a polymer as the active ingredient of an inoculum to raise antibodies and for protecting an animal host against infection by heat-labile enterotoxin-producing bacteria.

REFERENCES:
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patent: 4411888 (1983-10-01), Klipstein et al.
patent: 4454116 (1984-06-01), Brinton
patent: 4465665 (1984-08-01), Dorescu
Medical Hypothese, 5, 347-349, (1979).
Stimulus-Secretion Coupling in the Gastrointestinal Tract, 10, 108-109.
Infection and Immunity, (1983), 269-275, 42.
Journal of Bacteriology, Aug. 1983, vol. 155, pp. 728-733.
Biochemical and Biophysical Res. Commun., 320-325, (1983), vol. 112.
Infection and Immunity, (1982), 550-557, vol. 37.
Infection and Immunity, (1980), 91-97, vol. 29.
The Journal of Biological Chemistry, vol. 256, 7744-7746, (1981).
Proc. Nat'l Acad. Sci., 77, (1980), 4011-4015.

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