Multicellular living organisms and unmodified parts thereof and – Method of introducing a polynucleotide molecule into or... – Nonplant protein is expressed from the polynucleotide
Reexamination Certificate
2007-10-02
2007-10-02
Collins, Cynthia (Department: 1638)
Multicellular living organisms and unmodified parts thereof and
Method of introducing a polynucleotide molecule into or...
Nonplant protein is expressed from the polynucleotide
C800S293000, C800S294000, C800S298000, C800S312000, C800S317000, C800S317300, C800S008000, C800S320200, C435S320100, C435S419000, C435S430100, C435S469000, C435S470000, C435S069100, C426S046000, C426S598000, C426S622000, C426S629000, C426S634000
Reexamination Certificate
active
09743823
ABSTRACT:
A synthetic polynucleotide encoding human lactoferrin, modified with respect to the natural gene so as to maximize its expression in vegetals, on the basis of the preferential use of the codons is described. Moreover, the vectors containing such sequence, that having regulation elements activated in a controlled way determine its tissue- and stage-specific expression are further described. The vegetal cells and the plants transformed with the afore mentioned vectors, as well as the production processes of functional foods, vegetal milks, and human lactoferrin, utilizing them are also described.
REFERENCES:
patent: 6569831 (2003-05-01), Legrand et al.
patent: 91/13993 (1991-09-01), None
patent: 96/37094 (1996-11-01), None
patent: 98/06860 (1998-02-01), None
Mitra A. et al. Expression of a human lactoferrin cDNA in tobacco cells produces antibacterial protein(s). Plant Physiol. Nov. 1994;106(3):977-81.
Salmon V. et al. Production of Human Lactoferrin in Transgenic Tobacco Plants, Protein Expression and Purification, vol. 13, Issue 1, pp. 127-135, Jun. 1998.
Shen Q. et al. Modular nature of abscisic acid (ABA) response complexes: composite promoter units that are necessary and sufficient for ABA induction of gene expression in barley. Plant Cell. Jul. 1996;8(7):1107-1119.
Watanabe Y. et al. Nucleotide sequence of the basic 7S globulin gene from soybean. Plant Physiol. Jul. 1994;105(3):1019-20.
Parmenter D.L. et al. Production of biologically active hirudin in plant seeds using oleosin partitioning. Plant Mol Biol. Dec. 1995;29(6):1167-80.
van der Geest A. et al. A 68 bp element of the beta-phaseolin promoter functions as a seed-specific enhancer. Plant Mol Biol. Nov. 1996;32(4)579-88.
van der Geest A. et al. A 68 bp element of the beta-phaseolin promoter functions as a seed-specific enhancer. Plant Mol Biol. Nov. 1996;32(4):579-88.
Kagawa H. et al. Sequence of a cDNA encoding soybean basic 7S globulin. Nucleic Acids Res. Nov. 11, 1989;17(21):8868.
Shu T.F. et al. GenBank Accession U59425, Glycine max 7S seed globulin precursor, mRNA, complete cds. Jul. 3, 1996.
Mollet B. et al. Functional foods: at the frontier between food and pharma. Curr Opin Biotechnol. Oct. 2002;13(5):483-85.
Roberfroid M.B. Concepts and strategy of functional food science: the European perspective. Am J Clin Nutr. Jun. 2000;71(6 Suppl):1660S-4S; discussion 1674S-5S. Review.
Roberfroid M.B. Concepts in functional foods: the case of insulin and oligofructose. J Nutr. Jul. 1999;129(7 Suppl): 1398S-401S. Review.
Salmon, et al., “Production of Human Lactoferrin in Transgenic Tobacco Plants,” XP000863470,Protein Expression and Purification 13,Article PT980886, pp. 127-135 (1998).
Mitra, et al., “Expression of a Human Lactoferrin cDNA in Tobacco Cells Produces Antibacterial Protein (s),” XP002048441,Plant Physiol., pp. 977-981 (1994).
Ward, et al., “A System for Production of Commercial Quantities of Human Lactoferrin: A Broad Spectrum Natural Antibiotic,” XP002048442,Biotechnologyvol. 13, pp. 498-503 (1995).
Zhang, et al., Abstact of “Development of Transgenic Plants with Non-Plant Antibacterial Protein Genes for Resistance to Bacterial Pathogens Lactoferrin, Nicotiana Tabacum, Agrobacterium Tumefaciens,” XP002048439,Dissertation Abstracts International(1996).
Watanabe, et al., “Nucleotide Sequence of the Basic 7S Globulin Gene from Soybean,” XP002125177,Plant Physiol., pp. 1019-1020 (1994).
Lonnerdal, B. and S. Iyer, “Lactoferrin: Molecular Structure and Biological Function,”Annu. Rev. Nutr., vol. 15, pp. 93-110 (1995).
Okita, T.W. and J.C. Rogers, “Compartmentation of Proteins in the Endomembrane System of Plant Cells,”Annu. Rev. Plant Physiol. Plant Mol. Biol., vol. 47, pp. 327-350 (1996).
Pen, J., “Comparison of Host Sytstems for the Production of Recombinant Proteins,”Transgenic Plants: A Production System for Industrial and Pharmaceutical Proteins, J. Wiley & Sons, New York, Eds. M.R.L. Owen and J. Pen, Ch. 4, pp. 149-167 (1996).
Shewry, P.R., et al., “Seed Storage Proteins: Structures and Biosynthesis,”The Plant Cell, vol. 7, pp. 945-956 (Jul. 1995).
Stowell, K.M., et al., “Expression of cloned human lactoferrin in baby-hamster kidney cells,”Biochem. J., vol. 276, pp. 349-355 (1991).
Collins Cynthia
Nixon & Vanderhye P.C.
Plantechno S.r.l.
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