Synthetic polymeric drugs

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

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Details

5262381, 5262382, 530811, 530812, 530815, 530816, C08G 6348, C08G 6391

Patent

active

050378830

ABSTRACT:
A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moiety, and an optional cross-linkage, comprises:

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Ringsdorf et al., "Bis(2-Chloroethyl)Amine Bound to Copolymers of N-(2-Hydroxypropyl)Methacrylamide and Methacryloylated Oligopeptides via Biodegradable Bonds", Makromol. Chem., 188, 257-264 (1987).
Kopecek, Biomaterials, 5, 1984, 19-26, "Controlled Biodegradability of Polymers-A Key to Drug Delivery Systems".
Kopecek, Recent Advances in Drug Delivery Systems, Ed. Anderson et al., Plenum Press, New York (1984), "Synthesis of Tailor-Made Soluble Polymeric Drug Carriers", pp. 41-62.
Kopecek, IUPAC Macromolecules, Ed. Benoit et al., Pergamon Press, New York (1982), "Biodegradation of Polymers for Biomedical Use", pp. 305-319.

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