Synthetic, plasma-free, transfusible storage medium for red bloo

Details Synthetic, plasma-free, transfusible storage medium for red bloo Synthetic, plasma-free, transfusible storage medium for red bloo

1987-09-21

1990-10-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

435 2, A61K 3518, A01N 102

Patent

active

049619284

ABSTRACT:
The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days. The medium can also contain adenine.

REFERENCES:
patent: 2786014 (1957-03-01), Tullis
patent: 3629071 (1971-12-01), Sekhar
patent: 4390619 (1983-06-01), Harmening-Pittiglio
patent: 4447415 (1984-05-01), Rock et al.
Hematology, Williams et al., Sec. Ed. McGraw-Hill Book Co. (1977).
Remington's Pharmaceutical Sciences, Mack Publishing Co., 14th Ed. (1970), pp. 815 and 847.
Fenwal Laboratories (now Baxter Laboratories) Sales Literature of Jul., 1986.
Masouredis, S. P.: Perservation and Clinical Use of Erythrocytes and Whole Blood, Hematology, 3rd Ed.
Wood L. and Beutler E.: Storage of Erythrocytes in Artificial Media, Transfusion, 11:123 (1971).
Hogman, C. E.; Hedlund, K.: Zetterstrom, H.: Clinical Usefulness of Red Cells Preserved in Protein Poor Medium, N. Engl. J. Med. 229:1377 (1978).
Hogman, C. F.; Hedlund, K.; Akerblom, O. et al.: Red Cell Preservation in Protein-Poor Media, I. Leucocyte Enzymes as a Cause of Hemolysis, Transfusion 18:233 (1978).
Hogman, C. F.; Hedlund, K.; Sahlestrom, Y.: Red Cell Preservation in Protein-Poor Media III. Protection Against in vitro Hemolysis, Vox Sang 41:274 (1981).
Dawson, R. B.; Hershey, R. T.; Myers, C. et al.: Blood Preservation XXVI. CPD-Adenine Packed Cells: Benefits of Increasing the Glucose, Transfusion, 18:399 (1981).
Wolfe, L. C.: The Membrane and the Lesions of Storage in Preserved Red Cells, Transfusion, 25:185 (1985).
International Committee for Standardization in Haematology: Recommended Method for Radioisotope Red-Cell Survival Studies, Br. J. Haematol., 45:659 (1984).
Beutler, E.; West, C: Measurement of the Viability of Stored Red Cells by the Single-Isotope Technique Using .sup.51 Cr Analysis of Validity, Transfusion, 24:100 (1984).
An Article in the Scientific American, vol. 242, No. 6, Jun. 1980, (New York, U.S.) M. B. Zucker, "The Function of Blood Platelets".
Baldini et al., Blood 15:909 (1960).
An Article in The Merck Index, 9th Edition, 1976, (Merck & Co. Inc., Rahway, N.J., U.S.A.), "Sodium Citrate, Acid", p. 1112.
Baldini et al., Blood 16:1669 (1960).
Lovric, V. A.; Bryand, T.; Parker, A.: Improved Quality of Packed Cells, Med. J. Austr. 11:183 (1977).
Heaton, A.; Miripol, T.; Aster, R. et al.: Use of ADSOL Preservation Solution for Prolonged Storage of Low Viscosity AS-1 Red Blood Cells, Brit. J. Haematology, 57:467 (1984).
Mollison, P. L.: Methods of Determining the Posttransfusion Survival of Stored Red Cells, Transfusion 24:93 (1984).
Abstracts of the 18th Congress of the International Society of Blood Transfusion Munchen, Jul. 1984, p. 124.
Tullis et al., "Preserved Platelets", p. 462, Dept. of MED., Harvard Med. School (1958).
Biological Abstracts, vol. 81, No. 6, 1986, Biological Abstracts, Reports, Reviews and Meetings, vol. 28, 1985.
9-Biochem, Methods, vol. 91, 1979, 91:136650y.
Chemical Abstracts, vol. 77, 1972, 73201r.
An Abstract of Bagdwsarov et al., Preservation of Platelets and Their Clinical Use., p. 1667, Blood vol. 16.

Affiliated with

Also associated with

Rating

Synthetic, plasma-free, transfusible storage medium for red bloo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic, plasma-free, transfusible storage medium for red bloo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic, plasma-free, transfusible storage medium for red bloo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-972346