Synthetic, plasma-free, transfusible platelet storage medium

Details Synthetic, plasma-free, transfusible platelet storage medium Synthetic, plasma-free, transfusible platelet storage medium

1986-03-19

1987-09-22

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424127, 424153, 435 2, 43524031, A61K 3514, A01N 102

Patent

active

046954600

ABSTRACT:
The invention is a sterile, plasma-free platelet storage medium. The platelet storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 7.5 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The platelet storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The platelet storage medium is capable of storing and preserving platelets for at least 10 days.

REFERENCES:
patent: 2786014 (1957-03-01), Tullis
patent: 3629071 (1971-12-01), Sekhar
patent: 4390619 (1983-06-01), Harmening-Pittiglio
patent: 4447415 (1984-05-01), Rock et al.
9-Biochem, Methods, vol. 91, 1979, 91:136650y.
Chemical Abstracts, vol. 77, 1972, 73201r.
Remington's Pharmaceutical Sciences, Mack Publishing Co., 14th Edition (1970), pp. 815 to 847.
Hematology, Williams et al., Second Edition, McGraw-Hill Book Co., (1977), pp. 1553-1561.
Baldini et al., Blood, 15:909 (1960) and Bagdasarov et al., Blood, 16:1667 (1960).
Abstract by Adams et al., "Abstracts of the 18th Congress of the International Society of Blood Transfusion Munchen", Jul. 1984, p. 124.
Pages from article Tullis et al., "Preserved Platelets: Their Preparation Storage and Clinical Use, from the Dept. of Medicine and Biological Chemistry, Harvard Medical School (1958).
PCT application WO 85/02116 to Murphy.
Baldini et al., Blood, 16:1669 (1960), pp. 1669-1692.

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