Synthetic phosphatidyl cholines useful in forming liposomes

Details Synthetic phosphatidyl cholines useful in forming liposomes Synthetic phosphatidyl cholines useful in forming liposomes

1982-05-26

1984-11-27

Lovering, Richard D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

264 43, 264 46, 264 47, 424 11, 424 19, 424 38, 424178, 424199, 427 541, 4284022, 42840222, 428516, 560185, A23J 700, C07F 910

Patent

active

044850450

ABSTRACT:
Lower-.omega.-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the .omega.-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.

REFERENCES:
patent: Re30748 (1981-09-01), Sears
patent: 2002885 (1935-05-01), Detwiler et al.
patent: 2531275 (1950-11-01), Jones
patent: 2689863 (1954-09-01), Broderick et al.
patent: 4254115 (1981-03-01), Dawidson et al.
patent: 4320121 (1982-03-01), Sears

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