Synthetic peptides with bactericidal activity and endotoxin neut

Details Synthetic peptides with bactericidal activity and endotoxin neut Synthetic peptides with bactericidal activity and endotoxin neut

1994-03-24

1998-07-28

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 514 15, 514 21, 435 697, A61K 3812, A61K 3804

Patent

active

057863245

ABSTRACT:
The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are about 10 to 100 amino acids long and have bactericidal and/or endotoxin neutralizing activity. The peptides can be prepared by automated DNA synthesis or by recombinant DNA methods. The peptides are useful in methods to treat and prevent bacterial infection in the body and on surfaces. The peptides are also useful to treat endotoxin shock.

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