Synthetic peptides useful as universal carriers for the preparat

Details Synthetic peptides useful as universal carriers for the preparat Synthetic peptides useful as universal carriers for the preparat

1990-11-08

1993-03-23

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530322, 530324, 530327, 530403, 530405, 424 88, 424 89, 424 92, 930200, 930210, C07K 708, C07K 710, C07K 1700, A61K 39385

Patent

active

051965127

ABSTRACT:
The synthetic peptide TT3, the amino acid sequence of which corresponds to the region 947-967 of the tetanus toxin is recognized by different human Th cell clones in association with a wide range of alleles of the human major histocompatibility complex (MHC). Said peptide contains at least two epitopes, of which one (953-967) is recognized by the DR5-restricted clones and the other (947-960) is recognized by all other DR and DP alleles restricted clones. The TT3 peptide and the peptide corresponding to the 947-960 epitope can be used as universal carriers in the preparation of immunogenic conjugates consisting of at least one of said peptides and a natural or synthetic hapten derived from a pathogenic agent of interest.
The immunogenic conjugates are particularly suitable for preparing synthetic vaccines able to provide a protective immunity against different pathogenic agents which is not genetically restricted or is only slightly genetically restricted.

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