Synthetic peptides that inhibit leukocyte superoxide anion...

Details Synthetic peptides that inhibit leukocyte superoxide anion... Synthetic peptides that inhibit leukocyte superoxide anion...

2006-05-23

2006-05-23

Lukton, David (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

C530S324000, C530S325000, C514S002600, C514S012200, C514S013800

Reexamination Certificate

active

07049396

ABSTRACT:
Methods of inhibiting leukocyte O2−production and attracting leuckocytes using specific peptides are disclosed. These peptides include the proline-arginine (PR)-rich antimicrobial peptide known as PR-39 and truncated analogs thereof. These peptides can be used as medicaments that fight infection by attracting leukocytes to a wound site, yet restrict tissue damage at the wound site caused by excessive oxygen radicals produced by these leukocytes.

REFERENCES:
patent: 4605413 (1986-08-01), Urry et al.
patent: 4693718 (1987-09-01), Urry et al.
patent: 5028530 (1991-07-01), Lai et al.
patent: 5034510 (1991-07-01), Shiba et al.
patent: 5106735 (1992-04-01), Natori et al.
patent: 5118789 (1992-06-01), Natori
patent: 5166321 (1992-11-01), Lai et al.
patent: 5202420 (1993-04-01), Zasloff et al.
patent: 5206154 (1993-04-01), Lai et al.
patent: 5324716 (1994-06-01), Selsted et al.
patent: 5681933 (1997-10-01), Auron et al.
patent: 5731166 (1998-03-01), Geczy et al.
patent: 5759515 (1998-06-01), Rhodes et al.
patent: 5783170 (1998-07-01), Dean
patent: 5792444 (1998-08-01), Fischman et al.
patent: 5936066 (1999-08-01), Gubler et al.
patent: 6001649 (1999-12-01), Caput et al.
patent: 6090795 (2000-07-01), Yoshimura et al.
patent: 9609322 (1996-03-01), None
Shi et al.; Identification of a Proline-Arginine-Rich Antibacterial Peptide from Neutrophils that is Analogus to PR-39; J. Leukocyte Biol.; vol. 56, No. 6, Dec. 1994, pp. 8-7-811.
Agerberth et al.; Amino Acid Sequence of PR-39; Eur. J. Biochem. 202, 849-854.
Leto, Proc. Natl. Acad. Sci 91, 10650, 1994.
Sumimoto, Proc. Natl. Acad. Sci, 91, 5345, 1994.

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