Synthetic peptides specific for the detection of antibodies to H

Details Synthetic peptides specific for the detection of antibodies to H Synthetic peptides specific for the detection of antibodies to H

1990-07-26

1992-04-21

Lee, Lester L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 792, 514 12, 514 13, 514 14, 514 15, 530324, 530325, 530326, 530327, 530328, 530329, 530330, C12Q 170, C07K 708, C07K 710, G01N 3353

Patent

active

051067269

ABSTRACT:
The present invention relates to a method for the detection in body fluids of antibodies to hepatitis C virus (HCV), also known as a non-A non-B hepatitis (NANBH) virus and to the diagnosis of NANBH by the use of a composition of synthetic peptides. Each of these peptides has an amino acid sequence corresponding to immunodominant regions of a fusion protein and a non-structural polypeptide of HCV, SOD/HCV C100 and a postulated HCV structural (core) protein. More specifically, the present invention is directed to the use of a group of synthetic peptides in a prescribed sequence or their analogues for the detection of antibodies to HCV in body fluids. The detection method includes an enzyme-linked immunosorbent assay (ELISA), and other forms of immunoassay procedures.
The present invention also relates to a method for generating high titer antibodies to HCV in healthy mammals, including humans, by the use of compositions containing these synthetic peptides, analogues or mixtures thereof, in a free, conjugated or polymeric form as key components in synthetic vaccines for the prevention of non-A non-B hepatitis (NANBH).

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