Synthetic peptides sharing sequence homology with the HIV envelo

Details Synthetic peptides sharing sequence homology with the HIV envelo Synthetic peptides sharing sequence homology with the HIV envelo

1990-02-28

1992-01-14

Kepplinger, Esther L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530327, 530326, 530325, 530350, 514 2, 514 8, 514 10, 514 14, 514 13, 514 12, 514 21, 424 88, C07K 708, A61K 3718

Patent

active

050812262

ABSTRACT:
This invention relates to the identification of short peptide segments of AIDS virus proteins which elicit T cellular immunity, and to a method of inducing cellular immunity to native proteins of the AIDS virus by immunization with short synthetic peptides. Five potential peptides have been identified by searching for regions which can fold as a maximally amphipathic helix. These may be useful to include in either a synthetic peptide- or recombinant fragment- based vaccine.

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