Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2007-05-29
2007-05-29
Campell, Bruce R. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S069100
Reexamination Certificate
active
10738443
ABSTRACT:
Synthetic peptides immunoreactive with hepatitis A virus (HAV) antibodies are provided. The peptides are useful as laboratory reagents to detect or quantify HAV antibodies in biological samples in clinical or research-based assays and for inducing an immune response to HAV when administered to a human or animal. The peptides contain antigenic epitopes, modified antigenic epitopes or combinations of epitopes of the major structural capsid polypeptides or non-structural polypeptides of HAV and contain one or more molecules of the amino acid glutamine (Q) at the carboxyl end of the peptide, which enhances immunoreactivity and immunogenicity, particularly IgM antibody reactivity.
REFERENCES:
patent: 4391904 (1983-07-01), Litman et al.
patent: 4683202 (1987-07-01), Mullis
patent: 5426039 (1995-06-01), Wallace et al.
patent: 6838237 (2005-01-01), Fields et al.
patent: WO 89/06658 (1989-07-01), None
patent: WO 97/40147 (1997-10-01), None
Barringer et al., “Blunt-end and single-strand ligations byEscherichia coliligase: influence on an in vitro amplication scheme,”Gene89:117-122 (1990).
Beaucage and Caruthers, “Deoxynucleoside Phosphoramidites—A New Class of Key Intermediates for Deoxypolynucleotide Synthesis,”Tetrahedron Letts. 22(20):1859-1862 (1981).
Chang et al., “Antigenic Heterogeneity of the Hepatitis C Virus NS4 Protein as Modeled with Synthetic Peptides,”Virology257:177-190 (1999).
Gillam and Smith, “Site-Specific Mutagenesis Using Synthetic Oligodeoxyribonucleotide Primers: I. Optimum Conditions and minimum Oligodeoxyribonucleotide Length,”Gene8:81-97 (1979).
Guatelli et al., “Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication,”Proc. Natl. Acad. Sci. USA87:1874-1878 (Mar. 1990).
Jia et al., “Host Antibody Response to Viral Structural and Nonstructural Proteins after Hepatitis A Virus Infection,”J. Infect. Diseases165:273-280 (1992).
Khudyakov et al., “Antigenic Epitopes of the Hepatitis A Virus Polyprotein,”Virology260(2):260-272 (1999).
Kusov et al., “Synthetic peptide 62-75 VP3 of hepatitis A virus induces virus-binding antibodies,”Vopr. Virusol. 36(2):114-117 (1991) (Abstract).
Kwoh et al., “Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format,”Proc. Natl. Acad. Sci. USA86:1173-1177 (Feb. 1989).
Landegren et al., “A Ligase-Mediated Gene Detection Technique,”Science241:1077-1080 (Aug. 26, 1988).
Langer, “New Methods of Drug Delivery,”Science249:1527-1533 (Sep. 28, 1990).
Lomeli et al., “Quantitative Assays Based on the Use of Replicatable Hybridization Probes,”Clin. Chem.35(9):1826-1831 (1989).
Maxam and Gilbert, “Sequencing End-Labeled DNA with Base-Specific Chemical Cleavages,”Methods Enzymol.65(1):499-560 (1980).
Merrifield, “Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide,”J. Am. Chem. Soc.85:2149-2154 (Jul. 20, 1963).
Needham-VanDevanter et al., “Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex,”Nucl. Acid. Res.12(15):6159-6168 (1984).
Needleman and Wunsch, “A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins,”J. Mol. Biol.48:443-453 (1970).
Pearson and Regnier, “High-Performance Anion-Exchange Chromatography of Oligonucleotides,”J. Chrom.255:137-149 (1983).
Pearson and Lipman, “Improved tools for biological sequence comparison,”Proc. Natl. Acad. Sci. USA85:2444-2448 (Apr. 1988).
Ping et al., “Antigenic Structure of Human Hepatitis A Virus Defined by Analysis of Escape Mutants Selected against Murine Monoclonal Antibodies,”J. Virol.66(4):2208-2216 (1992).
Roberts et al., “Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering,”Nature328:731-734 (Aug. 20, 1987).
Robertson et al., “Antibody Response to Nonstructural Proteins of Hepatitis A Virus Following Infection,”J. Med. Virol.40:76-82 (1993).
Robertson et al., “Serological approaches to distinguish immune response to hepatitis A vaccine and natural infection,”Vaccine10(Supp. 1):S106-S109 (1992).
Smith and Waterman, “Comparison of Biosequences,”Adv. Appl. Math.2:482-489 (1981).
Sooknanan and Malek, “NASBA: A detection and amplification system uniquely suited for RNA,”Biotechnology13:563-564 (Jun. 1995).
Van Brunt, “Amplifying Genes: PCR and Its Alternatives,”Bio/Technology8:291-294 (Apr. 1990).
Wolff et al., “Direct Gene Transfer into Mouse Muscle in Vivo,”Science247:1465-1468 (Mar. 1990).
Wu and Wallace, “The Ligation Amplification Reaction (LAR)—Amplification of Specific DNA Sequences Using Sequential Rounds of Template-Dependent Ligation,”Genomics4:560-569 (1989).
Fields Howard A.
Khudyakov Yury E.
Campell Bruce R.
Centers for Disease Control
Horning Michelle
Needle & Rosenberg PC
LandOfFree
Synthetic peptides immunoreactive with hepatitis A virus... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthetic peptides immunoreactive with hepatitis A virus..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic peptides immunoreactive with hepatitis A virus... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3794345