Synthetic peptides for detoxification of bacterial endotoxins an

Details Synthetic peptides for detoxification of bacterial endotoxins an Synthetic peptides for detoxification of bacterial endotoxins an

1994-07-26

1996-12-31

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514 11, 514 16, 514 17, 514 18, 530317, 530330, 530327, 530328, 530329, A61K 3800, A61K 3812, C07K 500, C07K 700

Patent

active

055894593

ABSTRACT:
The present invention provides methods of using peptides of the formula R.sub.1 --(A--B--C).sub.n --R, wherein R.sub.1 and R are independently H or an amino acid residue or a fatty acid residue; A is an amino acid residue selected from the group consisting of Lys and Arg; B is an amino acid selected from the group consisting of Phe, Tyr, and Trp; C is an amino acid selected from the group consisting of Leu, Ile and Val; n is an integer of 1-100. The peptides are used for the removal of endotoxin from blood or sera; the detoxification of bacterial endotoxin; and the prevention of the contamination of products with endotoxin.

REFERENCES:
patent: 5358933 (1994-10-01), Porro
patent: 5371186 (1994-12-01), Porro
Shieh et al., FEBS Lett., vol. 252, No. 1, 2, pp. 121-124, Jul. 1989.
Danner et al., Antimicrobial Agents and Chemotherapy, vol. 33, No. 9, pp. 1428-1434, Sep. 1989.

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