Synthetic peptides for detoxification of bacterial endotoxins an

Details Synthetic peptides for detoxification of bacterial endotoxins an Synthetic peptides for detoxification of bacterial endotoxins an

1992-01-16

1994-12-06

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530317, 530327, 530329, 530330, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

053711866

ABSTRACT:
The present invention provides novel peptides of the formula R.sub.1 -(A-B-C).sub.n -R, where R.sub.1 and R are independently H or an amino acid residue or a fatty acid residue; A is an amino acid residue selected from the group consisting of Lys, Arg, and His; B is an amino acid selected from the group consisting of Phe, Tyr, and Trp; C is an amino acid selected from the group consisting of Leu, Ile and Val; n is an integer of 1-100. The peptides are used inter alia for the prevention and/or treatment of septic shock, for the detection of endotoxin and the preparation of antigenic complexes of Lipid A.

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