Synthetic peptides for an HIV-1 vaccine

Details Synthetic peptides for an HIV-1 vaccine Synthetic peptides for an HIV-1 vaccine

1995-06-06

1998-10-06

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 4241881, 4241841, 530350, 530324, 530325, 530326, A61K 3921, A61K 3900, A61K 3938, C07K 100

Patent

active

058173188

ABSTRACT:
The invention discloses the identification, characterization and use of a synthetic peptide, GPKEPFRDYVDRFYK (p24E), as a T-cell carrier for the appropriate assembly, with defined B-cell epitopes of the HIV-1 envelope protein, for the construction of potential synthetic vaccine candidates against HIV.

REFERENCES:
patent: 4925784 (1990-05-01), Crowl et al.
patent: 5013548 (1991-05-01), Haynes et al.
Cohen, 1993, "Jitters Jeopardize AIDS Vaccine Trial", Science 262: 980-981.
Fox, 1994, "No Winners Against AIDS", Biotechnology 12:128.
Sternberg, et al, 1987, "Prediction of antigenic determinants . . . "FEBS Letters 218(2): 231-237.

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