Synthetic peptides derived from the alpha-subunit of human lycop

Details Synthetic peptides derived from the alpha-subunit of human lycop Synthetic peptides derived from the alpha-subunit of human lycop

1988-03-17

1990-11-27

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 8, 530325, 530326, 530324, 530395, 530397, 530850, 530854, C07K 708, C07K 1514, A61K 3738, A61K 3702

Patent

active

049735780

ABSTRACT:
Synthetic peptides corresponding to .alpha.-subunit of human glycoprotein hormone amino acid regions .alpha.31-45, .alpha.21-35, .alpha.26-46 and .alpha.81-92; were found to inhibit binding of 125.sub.I-bTSH to human thyroid. Peptides corresponding to regions .alpha.26-46 and .alpha.31-45 were also found to potently inhibit the stimulation of adenylate cyclase activity by bTSH in a TSH bioassay using FRTL-5 cells and block the action of thyroid stimulating immunoglobulin.

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Smith
This invention was made with Government support under grant number HD 9140 by the National Institute of Health and funds from the Mayo Foundation. The Government has certain rights in the invention.

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